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Early disappearance of tumor antigen-reactive T cells from peripheral blood correlates with superior clinical outcomes in melanoma under anti-PD-1 therapy.
Bochem J, Zelba H, Spreuer J, Amaral T, Wagner NB, Gaissler A, Pop OT, Thiel K, Yurttas C, Soffel D, Forchhammer S, Sinnberg T, Niessner H, Meier F, Terheyden P, Königsrainer A, Garbe C, Flatz L, Pawelec G, Eigentler TK, Löffler MW, Weide B, Wistuba-Hamprecht K. Bochem J, et al. Among authors: flatz l. J Immunother Cancer. 2021 Dec;9(12):e003439. doi: 10.1136/jitc-2021-003439. J Immunother Cancer. 2021. PMID: 34933966 Free PMC article.
Tumor infiltrating lymphocytes in lymph node metastases of stage III melanoma correspond to response and survival in nine patients treated with ipilimumab at the time of stage IV disease.
Diem S, Hasan Ali O, Ackermann CJ, Bomze D, Koelzer VH, Jochum W, Speiser DE, Mertz KD, Flatz L. Diem S, et al. Among authors: flatz l. Cancer Immunol Immunother. 2018 Jan;67(1):39-45. doi: 10.1007/s00262-017-2061-4. Epub 2017 Sep 11. Cancer Immunol Immunother. 2018. PMID: 28894934 Free PMC article.
Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients.
Fässler M, Diem S, Mangana J, Hasan Ali O, Berner F, Bomze D, Ring S, Niederer R, Del Carmen Gil Cruz C, Pérez Shibayama CI, Krolik M, Siano M, Joerger M, Recher M, Risch L, Güsewell S, Risch M, Speiser DE, Ludewig B, Levesque MP, Dummer R, Flatz L. Fässler M, et al. Among authors: flatz l. J Immunother Cancer. 2019 Feb 20;7(1):50. doi: 10.1186/s40425-019-0523-2. J Immunother Cancer. 2019. PMID: 30786924 Free PMC article. Clinical Trial.
Prognostic and predictive value of PD-L2 DNA methylation and mRNA expression in melanoma.
Hoffmann F, Zarbl R, Niebel D, Sirokay J, Fröhlich A, Posch C, Holderried TAW, Brossart P, Saavedra G, Kuster P, Strieth S, Gielen GH, Ring SS, Dietrich J, Pietsch T, Flatz L, Kristiansen G, Landsberg J, Dietrich D. Hoffmann F, et al. Among authors: flatz l. Clin Epigenetics. 2020 Jun 26;12(1):94. doi: 10.1186/s13148-020-00883-9. Clin Epigenetics. 2020. PMID: 32586358 Free PMC article.
Molecular, clinicopathological, and immune correlates of LAG3 promoter DNA methylation in melanoma.
Fröhlich A, Sirokay J, Fietz S, Vogt TJ, Dietrich J, Zarbl R, Florin M, Kuster P, Saavedra G, Valladolid SR, Hoffmann F, Flatz L, Ring SS, Golletz C, Pietsch T, Strieth S, Brossart P, Gielen GH, Kristiansen G, Bootz F, Landsberg J, Dietrich D. Fröhlich A, et al. Among authors: flatz l. EBioMedicine. 2020 Sep;59:102962. doi: 10.1016/j.ebiom.2020.102962. Epub 2020 Aug 30. EBioMedicine. 2020. PMID: 32861198 Free PMC article.
CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8+ T Cells.
Braun M, Aguilera AR, Sundarrajan A, Corvino D, Stannard K, Krumeich S, Das I, Lima LG, Meza Guzman LG, Li K, Li R, Salim N, Jorge MV, Ham S, Kelly G, Vari F, Lepletier A, Raghavendra A, Pearson S, Madore J, Jacquelin S, Effern M, Quine B, Koufariotis LT, Casey M, Nakamura K, Seo EY, Hölzel M, Geyer M, Kristiansen G, Taheri T, Ahern E, Hughes BGM, Wilmott JS, Long GV, Scolyer RA, Batstone MD, Landsberg J, Dietrich D, Pop OT, Flatz L, Dougall WC, Veillette A, Nicholson SE, Möller A, Johnston RJ, Martinet L, Smyth MJ, Bald T. Braun M, et al. Among authors: flatz l. Immunity. 2020 Oct 13;53(4):805-823.e15. doi: 10.1016/j.immuni.2020.09.010. Immunity. 2020. PMID: 33053330 Free article.
Prognostic role of gamma-glutamyl transferase in metastatic melanoma patients treated with immune checkpoint inhibitors.
Winter J, Lenders MM, Gassenmaier M, Forschner A, Leiter U, Weide B, Purde MT, Flatz L, Cozzio A, Röcken M, Garbe C, Eigentler TK, Wagner NB. Winter J, et al. Among authors: flatz l. Cancer Immunol Immunother. 2021 Apr;70(4):1089-1099. doi: 10.1007/s00262-020-02768-5. Epub 2020 Oct 28. Cancer Immunol Immunother. 2021. PMID: 33113003 Free PMC article.
120 results