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Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.
Wellaway CR, Baldwin IR, Bamborough P, Barker D, Bartholomew MA, Chung CW, Dümpelfeld B, Evans JP, Fazakerley NJ, Homes P, Keeling SP, Lewell XQ, McNab FW, Morley J, Needham D, Neu M, van Oosterhout AJM, Pal A, Reinhard FBM, Rianjongdee F, Robertson CM, Rowland P, Shah RR, Sherriff EB, Sloan LA, Teague S, Thomas DA, Wellaway N, Wojno-Picon J, Woolven JM, Coe DM. Wellaway CR, et al. Among authors: van oosterhout ajm. J Med Chem. 2022 Jan 13;65(1):633-664. doi: 10.1021/acs.jmedchem.1c01765. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928601
Pulmonary Innate Lymphoid Cell Responses during Rhinovirus-induced Asthma Exacerbations In Vivo: A Clinical Trial.
Dhariwal J, Cameron A, Wong E, Paulsen M, Trujillo-Torralbo MB, Del Rosario A, Bakhsoliani E, Kebadze T, Almond M, Farne H, Gogsadze L, Aniscenko J, Rana BMJ, Hansel TT, Jackson DJ, Kon OM, Edwards MR, Solari R, Cousins DJ, Walton RP, Johnston SL; MRC-GSK Strategic Alliance Consortium. Dhariwal J, et al. Am J Respir Crit Care Med. 2021 Dec 1;204(11):1259-1273. doi: 10.1164/rccm.202010-3754OC. Am J Respir Crit Care Med. 2021. PMID: 34469272 Free PMC article. Clinical Trial.
Subcutaneous immunotherapy suppresses Th2 inflammation and induces neutralizing antibodies, but sublingual immunotherapy suppresses airway hyperresponsiveness in grass pollen mouse models for allergic asthma.
Hesse L, Brouwer U, Petersen AH, Gras R, Bosman L, Brimnes J, Oude Elberink JNG, van Oosterhout AJM, Nawijn MC. Hesse L, et al. Among authors: van oosterhout ajm. Clin Exp Allergy. 2018 Aug;48(8):1035-1049. doi: 10.1111/cea.13169. Epub 2018 Jun 8. Clin Exp Allergy. 2018. PMID: 29752757
A cellular census of human lungs identifies novel cell states in health and in asthma.
Vieira Braga FA, Kar G, Berg M, Carpaij OA, Polanski K, Simon LM, Brouwer S, Gomes T, Hesse L, Jiang J, Fasouli ES, Efremova M, Vento-Tormo R, Talavera-López C, Jonker MR, Affleck K, Palit S, Strzelecka PM, Firth HV, Mahbubani KT, Cvejic A, Meyer KB, Saeb-Parsy K, Luinge M, Brandsma CA, Timens W, Angelidis I, Strunz M, Koppelman GH, van Oosterhout AJ, Schiller HB, Theis FJ, van den Berge M, Nawijn MC, Teichmann SA. Vieira Braga FA, et al. Nat Med. 2019 Jul;25(7):1153-1163. doi: 10.1038/s41591-019-0468-5. Epub 2019 Jun 17. Nat Med. 2019. PMID: 31209336
DAMPs activating innate and adaptive immune responses in COPD.
Pouwels SD, Heijink IH, ten Hacken NH, Vandenabeele P, Krysko DV, Nawijn MC, van Oosterhout AJ. Pouwels SD, et al. Mucosal Immunol. 2014 Mar;7(2):215-26. doi: 10.1038/mi.2013.77. Epub 2013 Oct 23. Mucosal Immunol. 2014. PMID: 24150257 Free article. Review.
169 results