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Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities.
Christodoulou I, Ho WJ, Marple A, Ravich JW, Tam A, Rahnama R, Fearnow A, Rietberg C, Yanik S, Solomou EE, Varadhan R, Koldobskiy MA, Bonifant CL. Christodoulou I, et al. Among authors: varadhan r. J Immunother Cancer. 2021 Dec;9(12):e003894. doi: 10.1136/jitc-2021-003894. J Immunother Cancer. 2021. PMID: 34896980 Free PMC article.
A complex systems approach to aging biology.
Cohen AA, Ferrucci L, Fülöp T, Gravel D, Hao N, Kriete A, Levine ME, Lipsitz LA, Olde Rikkert MGM, Rutenberg A, Stroustrup N, Varadhan R. Cohen AA, et al. Among authors: varadhan r. Nat Aging. 2022 Jul;2(7):580-591. doi: 10.1038/s43587-022-00252-6. Epub 2022 Jul 20. Nat Aging. 2022. PMID: 37117782 Review.
The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia.
Karantanos T, Teodorescu P, Perkins B, Christodoulou I, Esteb C, Varadhan R, Helmenstine E, Rajkhowa T, Paun BC, Bonifant C, Dalton WB, Gondek LP, Moliterno AR, Levis MJ, Ghiaur G, Jones RJ. Karantanos T, et al. Among authors: varadhan r. Sci Adv. 2022 Feb 18;8(7):eabl8952. doi: 10.1126/sciadv.abl8952. Epub 2022 Feb 18. Sci Adv. 2022. PMID: 35179961 Free PMC article.
CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine.
Karantanos T, Teodorescu P, Arvanitis M, Perkins B, Jain T, DeZern AE, Dalton WB, Christodoulou I, Paun BC, Varadhan R, Esteb C, Rajkhowa T, Bonifant C, Gondek LP, Levis MJ, Yegnasubramanian S, Ghiaur G, Jones RJ. Karantanos T, et al. Among authors: varadhan r. Haematologica. 2023 Jul 1;108(7):1886-1899. doi: 10.3324/haematol.2022.281444. Haematologica. 2023. PMID: 36519323 Free PMC article.
Donor cell leukemia arising from clonal hematopoiesis after bone marrow transplantation.
Gondek LP, Zheng G, Ghiaur G, DeZern AE, Matsui W, Yegnasubramanian S, Lin MT, Levis M, Eshleman JR, Varadhan R, Tucker N, Jones R, Gocke CD. Gondek LP, et al. Among authors: varadhan r. Leukemia. 2016 Sep;30(9):1916-1920. doi: 10.1038/leu.2016.63. Epub 2016 Mar 15. Leukemia. 2016. PMID: 26975880 Free PMC article. No abstract available.
Timed sequential therapy for acute myelogenous leukemia: Results of a retrospective study of 301 patients and review of the literature.
Norsworthy KJ, DeZern AE, Tsai HL, Hand WA, Varadhan R, Gore SD, Gojo I, Pratz K, Carraway HE, Showel M, McDevitt MA, Gladstone D, Ghiaur G, Prince G, Seung AH, Benani D, Levis MJ, Karp JE, Smith BD. Norsworthy KJ, et al. Among authors: varadhan r. Leuk Res. 2017 Oct;61:25-32. doi: 10.1016/j.leukres.2017.08.009. Epub 2017 Aug 30. Leuk Res. 2017. PMID: 28869816 Free PMC article. Review.
Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning.
McCurdy SR, Radojcic V, Tsai HL, Vulic A, Thompson E, Ivcevic S, Kanakry CG, Powell JD, Lohman B, Adom D, Paczesny S, Cooke KR, Jones RJ, Varadhan R, Symons HJ, Luznik L. McCurdy SR, et al. Among authors: varadhan r. Blood. 2022 Jan 27;139(4):608-623. doi: 10.1182/blood.2021013054. Blood. 2022. PMID: 34657151 Free PMC article. Clinical Trial.
Nonmyeloablative Allogeneic Transplantation With Post-Transplant Cyclophosphamide for Acute Myeloid Leukemia With IDH Mutations: A Single Center Experience.
Ambinder A, Smith M, Tsai HL, Varadhan R, DeZern A, Dalton W, Gocke C, Webster J, Gondek L, Gojo I, Ali SA, Huff CA, Swinnen L, Wagner-Johnston N, Showel M, Prince G, Borrello I, Bolaños-Meade J, Luznik L, Jain T, Imus P, Fuchs E, Ambinder R, Gladstone DE, Levis M, Jones R, Ghiaur G, Smith BD. Ambinder A, et al. Among authors: varadhan r. Clin Lymphoma Myeloma Leuk. 2022 Apr;22(4):260-269. doi: 10.1016/j.clml.2021.09.022. Epub 2021 Oct 9. Clin Lymphoma Myeloma Leuk. 2022. PMID: 34750086 Free PMC article.
177 results