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Engineering CAR-NK cells to secrete IL-15 sustains their anti-AML functionality but is associated with systemic toxicities.
Christodoulou I, Ho WJ, Marple A, Ravich JW, Tam A, Rahnama R, Fearnow A, Rietberg C, Yanik S, Solomou EE, Varadhan R, Koldobskiy MA, Bonifant CL. Christodoulou I, et al. Among authors: bonifant cl. J Immunother Cancer. 2021 Dec;9(12):e003894. doi: 10.1136/jitc-2021-003894. J Immunother Cancer. 2021. PMID: 34896980 Free PMC article.
Improving CAR T-cells: The next generation.
Marple AH, Bonifant CL, Shah NN. Marple AH, et al. Among authors: bonifant cl. Semin Hematol. 2020 Jul;57(3):115-121. doi: 10.1053/j.seminhematol.2020.07.002. Epub 2020 Jul 23. Semin Hematol. 2020. PMID: 33256900 Review.
Converging genetic and epigenetic drivers of paediatric acute lymphoblastic leukaemia identified by an information-theoretic analysis.
Koldobskiy MA, Jenkinson G, Abante J, Rodriguez DiBlasi VA, Zhou W, Pujadas E, Idrizi A, Tryggvadottir R, Callahan C, Bonifant CL, Rabin KR, Brown PA, Ji H, Goutsias J, Feinberg AP. Koldobskiy MA, et al. Among authors: bonifant cl. Nat Biomed Eng. 2021 Apr;5(4):360-376. doi: 10.1038/s41551-021-00703-2. Epub 2021 Apr 15. Nat Biomed Eng. 2021. PMID: 33859388 Free PMC article.
Glycoprotein Targeted CAR-NK Cells for the Treatment of SARS-CoV-2 Infection.
Christodoulou I, Rahnama R, Ravich JW, Seo J, Zolov SN, Marple AN, Markovitz DM, Bonifant CL. Christodoulou I, et al. Among authors: bonifant cl. Front Immunol. 2021 Dec 23;12:763460. doi: 10.3389/fimmu.2021.763460. eCollection 2021. Front Immunol. 2021. PMID: 35003077 Free PMC article.
The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia.
Karantanos T, Teodorescu P, Perkins B, Christodoulou I, Esteb C, Varadhan R, Helmenstine E, Rajkhowa T, Paun BC, Bonifant C, Dalton WB, Gondek LP, Moliterno AR, Levis MJ, Ghiaur G, Jones RJ. Karantanos T, et al. Sci Adv. 2022 Feb 18;8(7):eabl8952. doi: 10.1126/sciadv.abl8952. Epub 2022 Feb 18. Sci Adv. 2022. PMID: 35179961 Free PMC article.
43 results