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TAS-116 inhibits oncogenic KIT signalling on the Golgi in both imatinib-naïve and imatinib-resistant gastrointestinal stromal tumours.
Saito Y, Takahashi T, Obata Y, Nishida T, Ohkubo S, Nakagawa F, Serada S, Fujimoto M, Ohkawara T, Nishigaki T, Sugase T, Koh M, Ishida T, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Nakajima K, Yamasaki M, Hirota S, Naka T, Mori M, Doki Y. Saito Y, et al. Among authors: nishida t. Br J Cancer. 2020 Mar;122(5):658-667. doi: 10.1038/s41416-019-0688-y. Epub 2019 Dec 20. Br J Cancer. 2020. PMID: 31857719 Free PMC article.
Combination of pimitespib (TAS-116) with sunitinib is an effective therapy for imatinib-resistant gastrointestinal stromal tumors.
Teranishi R, Takahashi T, Obata Y, Nishida T, Ohkubo S, Kazuno H, Saito Y, Serada S, Fujimoto M, Kurokawa Y, Saito T, Yamamoto K, Yamashita K, Tanaka K, Makino T, Nakajima K, Hirota S, Naka T, Eguchi H, Doki Y. Teranishi R, et al. Among authors: nishida t. Int J Cancer. 2023 Jun 15;152(12):2580-2593. doi: 10.1002/ijc.34461. Epub 2023 Feb 21. Int J Cancer. 2023. PMID: 36752576
SOCS1 gene therapy has antitumor effects in imatinib-resistant gastrointestinal stromal tumor cells through FAK/PI3 K signaling.
Sugase T, Takahashi T, Serada S, Fujimoto M, Ohkawara T, Hiramatsu K, Nishida T, Hirota S, Saito Y, Tanaka K, Miyazaki Y, Makino T, Kurokawa Y, Yamasaki M, Nakajima K, Hanasaki K, Kishimoto T, Mori M, Doki Y, Naka T. Sugase T, et al. Among authors: nishida t. Gastric Cancer. 2018 Nov;21(6):968-976. doi: 10.1007/s10120-018-0822-1. Epub 2018 Apr 5. Gastric Cancer. 2018. PMID: 29623544
Genomic and transcriptomic analysis of imatinib resistance in gastrointestinal stromal tumors.
Takahashi T, Elzawahry A, Mimaki S, Furukawa E, Nakatsuka R, Nakamura H, Nishigaki T, Serada S, Naka T, Hirota S, Shibata T, Tsuchihara K, Nishida T, Kato M. Takahashi T, et al. Among authors: nishida t. Genes Chromosomes Cancer. 2017 Apr;56(4):303-313. doi: 10.1002/gcc.22438. Epub 2017 Jan 23. Genes Chromosomes Cancer. 2017. PMID: 27997714 Free PMC article.
Clinical significance of surgical intervention for imatinib-resistant gastrointestinal stromal tumors in the era of multiple tyrosine kinase inhibitors.
Wada N, Takahashi T, Kurokawa Y, Nakajima K, Nishida T, Koh M, Akamaru Y, Motoori M, Kimura Y, Tanaka K, Miyazaki Y, Makino T, Yamasaki M, Eguchi H, Doki Y. Wada N, et al. Among authors: nishida t. Surg Today. 2021 Sep;51(9):1506-1512. doi: 10.1007/s00595-021-02241-5. Epub 2021 Feb 11. Surg Today. 2021. PMID: 33570662
2,776 results