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An H3F3A K27M-mutation in a sonic hedgehog medulloblastoma.
Dottermusch M, Uksul N, Knappe UJ, Erdlenbruch B, Wefers AK. Dottermusch M, et al. Among authors: wefers ak. Brain Pathol. 2022 May;32(3):e13024. doi: 10.1111/bpa.13024. Epub 2021 Nov 7. Brain Pathol. 2022. PMID: 34747078 Free PMC article.
The Diagnostic Impact of Epigenomics in Pituicyte-derived Tumors: Report of an Unusual Sellar Lesion with Extensive Hemorrhage and Necrotic Debris.
Dottermusch M, Rotermund R, Ricklefs FL, Wefers AK, Saeger W, Flitsch J, Glatzel M, Matschke J. Dottermusch M, et al. Among authors: wefers ak. Endocr Pathol. 2022 Sep;33(3):411-413. doi: 10.1007/s12022-022-09727-z. Epub 2022 Aug 3. Endocr Pathol. 2022. PMID: 35921032 Free PMC article. No abstract available.
Atypical neurofibromas reveal distinct epigenetic features with proximity to benign peripheral nerve sheath tumor entities.
Kresbach C, Dottermusch M, Eckhardt A, Ristow I, Paplomatas P, Altendorf L, Wefers AK, Bockmayr M, Belakhoua S, Tran I, Pohl L, Neyazi S, Bode H, Farschtschi S, Well L, Friedrich RE, Reuss D, Snuderl M, Hagel C, Mautner VF, Schüller U. Kresbach C, et al. Among authors: wefers ak. Neuro Oncol. 2023 Sep 5;25(9):1644-1655. doi: 10.1093/neuonc/noad053. Neuro Oncol. 2023. PMID: 36866403 Free PMC article.
MiR-34a deficiency accelerates medulloblastoma formation in vivo.
Thor T, Künkele A, Pajtler KW, Wefers AK, Stephan H, Mestdagh P, Heukamp L, Hartmann W, Vandesompele J, Sadowski N, Becker L, Garrett L, Hölter SM, Horsch M, Calzada-Wack J, Klein-Rodewald T, Racz I, Zimmer A, Beckers J, Neff F, Klopstock T, De Antonellis P, Zollo M, Wurst W, Fuchs H, Gailus-Durner V, Schüller U, de Angelis MH, Eggert A, Schramm A, Schulte JH. Thor T, et al. Among authors: wefers ak. Int J Cancer. 2015 May 15;136(10):2293-303. doi: 10.1002/ijc.29294. Epub 2014 Nov 25. Int J Cancer. 2015. PMID: 25348795 Free article.
A mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors.
Neumann JE, Wefers AK, Lambo S, Bianchi E, Bockstaller M, Dorostkar MM, Meister V, Schindler P, Korshunov A, von Hoff K, Nowak J, Warmuth-Metz M, Schneider MR, Renner-Müller I, Merk DJ, Shakarami M, Sharma T, Chavez L, Glass R, Chan JA, Taketo MM, Neumann P, Kool M, Schüller U. Neumann JE, et al. Among authors: wefers ak. Nat Med. 2017 Oct;23(10):1191-1202. doi: 10.1038/nm.4402. Epub 2017 Sep 11. Nat Med. 2017. PMID: 28892064
Subgroup-specific localization of human medulloblastoma based on pre-operative MRI.
Wefers AK, Warmuth-Metz M, Pöschl J, von Bueren AO, Monoranu CM, Seelos K, Peraud A, Tonn JC, Koch A, Pietsch T, Herold-Mende C, Mawrin C, Schouten-van Meeteren A, van Vuurden D, von Hoff K, Rutkowski S, Pfister SM, Kool M, Schüller U. Wefers AK, et al. Acta Neuropathol. 2014;127(6):931-3. doi: 10.1007/s00401-014-1271-5. Epub 2014 Apr 4. Acta Neuropathol. 2014. PMID: 24699697 No abstract available.
Rosette-forming glioneuronal tumors share a distinct DNA methylation profile and mutations in FGFR1, with recurrent co-mutation of PIK3CA and NF1.
Sievers P, Appay R, Schrimpf D, Stichel D, Reuss DE, Wefers AK, Reinhardt A, Coras R, Ruf VC, Schmid S, de Stricker K, Boldt HB, Kristensen BW, Petersen JK, Ulhøi BP, Gardberg M, Aronica E, Hasselblatt M, Brück W, Bielle F, Mokhtari K, Lhermitte B, Wick W, Herold-Mende C, Hänggi D, Brandner S, Giangaspero F, Capper D, Rushing E, Wesseling P, Pfister SM, Figarella-Branger D, von Deimling A, Sahm F, Jones DTW. Sievers P, et al. Among authors: wefers ak. Acta Neuropathol. 2019 Sep;138(3):497-504. doi: 10.1007/s00401-019-02038-4. Epub 2019 Jun 27. Acta Neuropathol. 2019. PMID: 31250151 Free article.
Risk prediction in early childhood sonic hedgehog medulloblastoma treated with radiation-avoiding chemotherapy: Evidence for more than 2 subgroups.
Tonn S, Korshunov A, Obrecht D, Sill M, Spohn M, von Hoff K, Milde T, Pietsch T, Goschzik T, Bison B, Juhnke BO, Struve N, Sturm D, Sahm F, Bockmayr M, Friedrich C, von Bueren AO, Gerber NU, Benesch M, Jones DTW, Kool M, Wefers AK, Schüller U, Pfister SM, Rutkowski S, Mynarek M. Tonn S, et al. Among authors: wefers ak. Neuro Oncol. 2023 Aug 3;25(8):1518-1529. doi: 10.1093/neuonc/noad027. Neuro Oncol. 2023. PMID: 36715306 Free PMC article.
A prognostic neural epigenetic signature in high-grade glioma.
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire CL, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers AK, Neumann JE, Bode H, Hausmann F, Huber TB, Bonn S, Jütten K, Delev D, Weber KJ, Harter PN, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Göller PC, Sahm F, Menstel JA, Zimmer DN, Keough MB, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà ML, Krishna S, Hervey-Jumper SL, Schüller U, Heiland DH, Hänzelmann S, Ricklefs FL. Drexler R, et al. Among authors: wefers ak. Nat Med. 2024 May 17. doi: 10.1038/s41591-024-02969-w. Online ahead of print. Nat Med. 2024. PMID: 38760585
64 results