O'Dwyer PJ - Search Results

1

Safety, pharmacokinetic, pharmacodynamic and clinical activity of molibresib for the treatment of nuclear protein in testis carcinoma and other cancers: Results of a Phase I/II open-label, dose escalation study.

Cousin S, Blay JY, Garcia IB, de Bono JS, Le Tourneau C, Moreno V, Trigo J, Hann CL, Azad AA, Im SA, Cassier PA, French CA, Italiano A, Keedy VL, Plummer R, Sablin MP, Hemming ML, Ferron-Brady G, Wyce A, Khaled A, Datta A, Foley SW, McCabe MT, Wu Y, Horner T, Kremer BE, Dhar A, O'Dwyer PJ, Shapiro GI, Piha-Paul SA. Cousin S, et al. Int J Cancer. 2022 Mar 15;150(6):993-1006. doi: 10.1002/ijc.33861. Epub 2021 Nov 26. Int J Cancer. 2022. PMID: 34724226 Free article. Clinical Trial.

2

Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors.

Piha-Paul SA, Hann CL, French CA, Cousin S, Braña I, Cassier PA, Moreno V, de Bono JS, Harward SD, Ferron-Brady G, Barbash O, Wyce A, Wu Y, Horner T, Annan M, Parr NJ, Prinjha RK, Carpenter CL, Hilton J, Hong DS, Haas NB, Markowski MC, Dhar A, O'Dwyer PJ, Shapiro GI. Piha-Paul SA, et al. JNCI Cancer Spectr. 2019 Nov 6;4(2):pkz093. doi: 10.1093/jncics/pkz093. eCollection 2020 Apr. JNCI Cancer Spectr. 2019. PMID: 32328561 Free PMC article.

3

Characterization of Neutropenia in Advanced Cancer Patients Following Palbociclib Treatment Using a Population Pharmacokinetic-Pharmacodynamic Modeling and Simulation Approach.

Sun W, O'Dwyer PJ, Finn RS, Ruiz-Garcia A, Shapiro GI, Schwartz GK, DeMichele A, Wang D. Sun W, et al. J Clin Pharmacol. 2017 Sep;57(9):1159-1173. doi: 10.1002/jcph.902. Epub 2017 Apr 18. J Clin Pharmacol. 2017. PMID: 28419480 Clinical Trial.

4

Phase 1 and pharmacodynamic trial of everolimus in combination with cetuximab in patients with advanced cancer.

Ciunci CA, Perini RF, Avadhani AN, Kang HC, Sun W, Redlinger M, Harlacker K, Flaherty KT, Giantonio BJ, Rosen MA, Divgi CR, Song HK, Englander S, Troxel A, Schnall M, O'Dwyer PJ. Ciunci CA, et al. Cancer. 2014 Jan 1;120(1):77-85. doi: 10.1002/cncr.28294. Epub 2013 Sep 24. Cancer. 2014. PMID: 24108668 Free article. Clinical Trial.

5

Phase 2 trial of the cyclin-dependent kinase 4/6 inhibitor palbociclib in patients with retinoblastoma protein-expressing germ cell tumors.

Vaughn DJ, Hwang WT, Lal P, Rosen MA, Gallagher M, O'Dwyer PJ. Vaughn DJ, et al. Cancer. 2015 May 1;121(9):1463-8. doi: 10.1002/cncr.29213. Epub 2014 Dec 18. Cancer. 2015. PMID: 25522918 Free article. Clinical Trial.

6

Dose escalation study of tezacitabine in combination with cisplatin in patients with advanced cancer.

Flaherty KT, Stevenson JP, Gallagher M, Giantonio B, Algazy KM, Sun W, Haller DG, O'Dwyer PJ. Flaherty KT, et al. Cancer. 2003 Apr 15;97(8):1985-90. doi: 10.1002/cncr.11273. Cancer. 2003. PMID: 12673728 Free article. Clinical Trial.

7

Phase I pharmacokinetic study of intraperitoneal etoposide.

O'Dwyer PJ, LaCreta FP, Daugherty JP, Hogan M, Rosenblum NG, O'Dwyer JL, Comis RL. O'Dwyer PJ, et al. Cancer Res. 1991 Apr 15;51(8):2041-6. Cancer Res. 1991. PMID: 2009523 Clinical Trial.

8

Phase I, dose-escalation trial of the oral cyclin-dependent kinase 4/6 inhibitor PD 0332991, administered using a 21-day schedule in patients with advanced cancer.

Flaherty KT, Lorusso PM, Demichele A, Abramson VG, Courtney R, Randolph SS, Shaik MN, Wilner KD, O'Dwyer PJ, Schwartz GK. Flaherty KT, et al. Clin Cancer Res. 2012 Jan 15;18(2):568-76. doi: 10.1158/1078-0432.CCR-11-0509. Epub 2011 Nov 16. Clin Cancer Res. 2012. PMID: 22090362 Clinical Trial.

9

Phase I and pharmacokinetic trial of the proapoptotic sulindac analog CP-461 in patients with advanced cancer.

Sun W, Stevenson JP, Gallo JM, Redlinger M, Haller D, Algazy K, Giantonio B, Alila H, O'Dwyer PJ. Sun W, et al. Clin Cancer Res. 2002 Oct;8(10):3100-4. Clin Cancer Res. 2002. PMID: 12374677 Clinical Trial.

10

A phase I trial of topotecan and gemcitabine administered weekly for 3 consecutive weeks to patients with advanced tumors.

Sun W, Stevenson JP, Gallagher M, Giantonio B, Algazy K, Haller D, Vaughn D, Raskay BJ, O'Dwyer PJ. Sun W, et al. Cancer. 2001 Jul 15;92(2):414-9. doi: 10.1002/1097-0142(20010715)92:2<414::aid-cncr1337>3.0.co;2-w. Cancer. 2001. PMID: 11466697 Clinical Trial.

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