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Page 1
The Combination of Gefitinib With ATRA and ATO Induces Myeloid Differentiation in Acute Promyelocytic Leukemia Resistant Cells.
de Almeida LY, Pereira-Martins DA, Weinhäuser I, Ortiz C, Cândido LA, Lange AP, De Abreu NF, Mendonza SES, de Deus Wagatsuma VM, Do Nascimento MC, Paiva HH, Alves-Paiva RM, Bonaldo CCOM, Nascimento DC, Alves-Filho JC, Scheucher PS, Lima ASG, Schuringa JJ, Ammantuna E, Ottone T, Noguera NI, Araujo CL, Rego EM. de Almeida LY, et al. Among authors: schuringa jj. Front Oncol. 2021 Sep 28;11:686445. doi: 10.3389/fonc.2021.686445. eCollection 2021. Front Oncol. 2021. PMID: 34650910 Free PMC article.
Reduced SLIT2 is Associated with Increased Cell Proliferation and Arsenic Trioxide Resistance in Acute Promyelocytic Leukemia.
Weinhäuser I, Pereira-Martins DA, Ortiz C, Silveira DR, Simões LAA, Bianco TM, Araujo CL, Koury LC, Melo RAM, Bittencourt RI, Pagnano K, Pasquini R, Nunes EC, Fagundes EM, Gloria AB, Kerbauy F, Chauffaille ML, Keating A, Tallman MS, Ribeiro RC, Dillon R, Ganser A, Löwenberg B, Valk P, Lo-Coco F, Sanz MA, Berliner N, Ammatuna E, Lucena-Araujo AR, Schuringa JJ, Rego EM. Weinhäuser I, et al. Among authors: schuringa jj. Cancers (Basel). 2020 Oct 27;12(11):3134. doi: 10.3390/cancers12113134. Cancers (Basel). 2020. PMID: 33120864 Free PMC article.
MLL5 improves ATRA driven differentiation and promotes xenotransplant engraftment in acute promyelocytic leukemia model.
Pereira-Martins DA, Weinhäuser I, Coelho-Silva JL, França-Neto PL, Almeida LY, Bianco TM, Silva CL, França RF, Traina F, Rego EM, Schuringa JJ, Lucena-Araujo AR. Pereira-Martins DA, et al. Among authors: schuringa jj. Cell Death Dis. 2021 Apr 6;12(4):371. doi: 10.1038/s41419-021-03604-z. Cell Death Dis. 2021. PMID: 33824267 Free PMC article.
The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia.
Thomé CH, Ferreira GA, Pereira-Martins DA, Augusto Dos Santos G, Almeida-Silveira DR, Weinhäuser I, Antônio de Souza G, Houtsma R, Schuringa JJ, Rego EM, Faça VM. Thomé CH, et al. Among authors: schuringa jj. Mol Cell Proteomics. 2021;20:100091. doi: 10.1016/j.mcpro.2021.100091. Epub 2021 May 7. Mol Cell Proteomics. 2021. PMID: 33971369 Free PMC article.
The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia.
Erdem A, Marin S, Pereira-Martins DA, Cortés R, Cunningham A, Pruis MG, de Boer B, van den Heuvel FAJ, Geugien M, Wierenga ATJ, Brouwers-Vos AZ, Rego EM, Huls G, Cascante M, Schuringa JJ. Erdem A, et al. Among authors: schuringa jj. Nat Commun. 2022 Mar 1;13(1):1105. doi: 10.1038/s41467-022-28737-3. Nat Commun. 2022. PMID: 35232995 Free PMC article.
Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability.
Erdem A, Marin S, Pereira-Martins DA, Geugien M, Cunningham A, Pruis MG, Weinhäuser I, Gerding A, Bakker BM, Wierenga ATJ, Rego EM, Huls G, Cascante M, Schuringa JJ. Erdem A, et al. Among authors: schuringa jj. Nat Commun. 2022 Apr 19;13(1):2013. doi: 10.1038/s41467-022-29639-0. Nat Commun. 2022. PMID: 35440568 Free PMC article.
Dietary methionine starvation impairs acute myeloid leukemia progression.
Cunningham A, Erdem A, Alshamleh I, Geugien M, Pruis M, Pereira-Martins DA, van den Heuvel FAJ, Wierenga ATJ, Ten Berge H, Dennebos R, van den Boom V, Hogeling SM, Weinhäuser I, Knops R, de Blaauw P, Heiner-Fokkema MR, Woolthuis C, Günther UL, Rego EM, Martens JHA, Jansen JH, Schwalbe H, Huls G, Schuringa JJ. Cunningham A, et al. Among authors: schuringa jj. Blood. 2022 Nov 10;140(19):2037-2052. doi: 10.1182/blood.2022017575. Blood. 2022. PMID: 35984907 Free article.
Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia.
Pereira-Martins DA, Coelho-Silva JL, Weinhäuser I, Franca-Neto PL, Silveira DR, Ortiz C, Moreira-Aguiar A, Lima MM, Koury LC, de Melo RA, Glória AB, Fagundes EM, Lino BK, Pagnano K, Bittencourt R, Nunes E, Traina F, Figueiredo-Pontes L, Keating A, Tallman MS, Ribeiro RC, Dilon R, Ganser A, Sanz MA, Berliner N, Valk P, Löwenberg B, Ottone T, Noguera NI, Voso MT, Paoloni F, Fazi P, Ammatuna E, Huls G, Schuringa JJ, Rego EM, Lucena-Araujo AR. Pereira-Martins DA, et al. Among authors: schuringa jj. Br J Haematol. 2023 Jan;200(2):170-174. doi: 10.1111/bjh.18510. Epub 2022 Oct 20. Br J Haematol. 2023. PMID: 36263593
The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy.
Lima K, Pereira-Martins DA, de Miranda LBL, Coelho-Silva JL, Leandro GDS, Weinhäuser I, Cavaglieri RC, Leal AM, da Silva WF, Lange APAL, Velloso EDRP, Griessinger E, Hilberink JR, Ammatuna E, Huls G, Schuringa JJ, Rego EM, Machado-Neto JA. Lima K, et al. Among authors: schuringa jj. Blood Cancer J. 2022 Nov 9;12(11):151. doi: 10.1038/s41408-022-00747-w. Blood Cancer J. 2022. PMID: 36347832 Free PMC article.
137 results