O'Kane CM - Search Results

1

Mesenchymal Stromal Cells: an Antimicrobial and Host-Directed Therapy for Complex Infectious Diseases.

Shaw TD, Krasnodembskaya AD, Schroeder GN, Zumla A, Maeurer M, O'Kane CM. Shaw TD, et al. Clin Microbiol Rev. 2021 Dec 15;34(4):e0006421. doi: 10.1128/CMR.00064-21. Epub 2021 Oct 6. Clin Microbiol Rev. 2021. PMID: 34612662 Free PMC article.

2

Mitochondrial Transfer via Tunneling Nanotubes is an Important Mechanism by Which Mesenchymal Stem Cells Enhance Macrophage Phagocytosis in the In Vitro and In Vivo Models of ARDS.

Jackson MV, Morrison TJ, Doherty DF, McAuley DF, Matthay MA, Kissenpfennig A, O'Kane CM, Krasnodembskaya AD. Jackson MV, et al. Stem Cells. 2016 Aug;34(8):2210-23. doi: 10.1002/stem.2372. Epub 2016 Apr 29. Stem Cells. 2016. PMID: 27059413 Free PMC article.

3

Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer.

Morrison TJ, Jackson MV, Cunningham EK, Kissenpfennig A, McAuley DF, O'Kane CM, Krasnodembskaya AD. Morrison TJ, et al. Am J Respir Crit Care Med. 2017 Nov 15;196(10):1275-1286. doi: 10.1164/rccm.201701-0170OC. Am J Respir Crit Care Med. 2017. PMID: 28598224 Free PMC article.

4

Hypercapnic acidosis induces mitochondrial dysfunction and impairs the ability of mesenchymal stem cells to promote distal lung epithelial repair.

Fergie N, Todd N, McClements L, McAuley D, O'Kane C, Krasnodembskaya A. Fergie N, et al. FASEB J. 2019 Apr;33(4):5585-5598. doi: 10.1096/fj.201802056R. Epub 2019 Jan 16. FASEB J. 2019. PMID: 30649987 Free PMC article.

5

Emerging drugs for treating the acute respiratory distress syndrome.

Shaw TD, McAuley DF, O'Kane CM. Shaw TD, et al. Expert Opin Emerg Drugs. 2019 Mar;24(1):29-41. doi: 10.1080/14728214.2019.1591369. Epub 2019 Mar 18. Expert Opin Emerg Drugs. 2019. PMID: 30841764 Review.

6

Reducing mortality and morbidity in patients with severe COVID-19 disease by advancing ongoing trials of Mesenchymal Stromal (stem) Cell (MSC) therapy - Achieving global consensus and visibility for cellular host-directed therapies.

Zumla A, Wang FS, Ippolito G, Petrosillo N, Agrati C, Azhar EI, Chang C, El-Kafrawy SA, Osman M, Zitvogel L, Galle PR, Locatelli F, Gorman E, Cordon-Cardo C, O'Kane C, McAuley D, Maeurer M. Zumla A, et al. Int J Infect Dis. 2020 Jul;96:431-439. doi: 10.1016/j.ijid.2020.05.040. Epub 2020 May 17. Int J Infect Dis. 2020. PMID: 32425638 Free PMC article.

7

Mesenchymal stromal cells for acute respiratory distress syndrome (ARDS), sepsis, and COVID-19 infection: optimizing the therapeutic potential.

Gorman E, Millar J, McAuley D, O'Kane C. Gorman E, et al. Expert Rev Respir Med. 2021 Mar;15(3):301-324. doi: 10.1080/17476348.2021.1848555. Epub 2020 Nov 26. Expert Rev Respir Med. 2021. PMID: 33172313 Review.

8

Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS.

Dutra Silva J, Su Y, Calfee CS, Delucchi KL, Weiss D, McAuley DF, O'Kane C, Krasnodembskaya AD. Dutra Silva J, et al. Eur Respir J. 2021 Jul 1;58(1):2002978. doi: 10.1183/13993003.02978-2020. Print 2021 Jul. Eur Respir J. 2021. PMID: 33334945 Free PMC article.

9

Precision-cut lung slices: A powerful ex vivo model to investigate respiratory infectious diseases.

Viana F, O'Kane CM, Schroeder GN. Viana F, et al. Mol Microbiol. 2022 Mar;117(3):578-588. doi: 10.1111/mmi.14817. Epub 2021 Oct 31. Mol Microbiol. 2022. PMID: 34570407 Free PMC article. Review.

10

Repair of acute respiratory distress syndrome by stromal cell administration (REALIST) trial: A phase 1 trial.

Gorman E, Shankar-Hari M, Hopkins P, Tunnicliffe WS, Perkins GD, Silversides J, McGuigan P, Krasnodembskaya A, Jackson C, Boyle R, McFerran J, McDowell C, Campbell C, McFarland M, Smythe J, Thompson J, Williams B, Curley G, Laffey JG, Clarke M, McAuley DF, O'Kane CM. Gorman E, et al. EClinicalMedicine. 2021 Oct 24;41:101167. doi: 10.1016/j.eclinm.2021.101167. eCollection 2021 Nov. EClinicalMedicine. 2021. PMID: 34746723 Free PMC article.

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