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Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators.
Ayoub SM, Piscitelli F, Silvestri C, Limebeer CL, Rock EM, Smoum R, Farag M, de Almeida H, Sullivan MT, Lacroix S, Boubertakh B, Nallabelli N, Lichtman AH, Leri F, Mechoulam R, Di Marzo V, Parker LA. Ayoub SM, et al. Among authors: smoum r. Front Pharmacol. 2021 Sep 15;12:706703. doi: 10.3389/fphar.2021.706703. eCollection 2021. Front Pharmacol. 2021. PMID: 34603019 Free PMC article.
N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.
Donvito G, Piscitelli F, Muldoon P, Jackson A, Vitale RM, D'Aniello E, Giordano C, Ignatowska-Jankowska BM, Mustafa MA, Guida F, Petrie GN, Parker L, Smoum R, Sim-Selley L, Maione S, Lichtman AH, Damaj MI, Di Marzo V, Mechoulam R. Donvito G, et al. Among authors: smoum r. Neuropharmacology. 2019 Apr;148:320-331. doi: 10.1016/j.neuropharm.2018.03.020. Epub 2018 Mar 19. Neuropharmacology. 2019. PMID: 29567093 Free PMC article.
Bioactive lipids ALIAmides differentially modulate inflammatory responses of distinct subsets of primary human T lymphocytes.
Chiurchiù V, Leuti A, Smoum R, Mechoulam R, Maccarrone M. Chiurchiù V, et al. Among authors: smoum r. FASEB J. 2018 Oct;32(10):5716-5723. doi: 10.1096/fj.201800107R. Epub 2018 Jun 7. FASEB J. 2018. PMID: 29879374
Our findings show for the first time that specific ALIAmides can directly affect different T-cell subsets, and provide proof of their anti-inflammatory role in chronic inflammation, ultimately suggesting that these bioactive lipids could offer novel tools for the management of T- …
Our findings show for the first time that specific ALIAmides can directly affect different T-cell subsets, and provide proof of their anti-i …
Oleoyl glycine: interference with the aversive effects of acute naloxone-precipitated MWD, but not morphine reward, in male Sprague-Dawley rats.
Petrie GN, Wills KL, Piscitelli F, Smoum R, Limebeer CL, Rock EM, Humphrey AE, Sheppard-Perkins M, Lichtman AH, Mechoulam R, Di Marzo V, Parker LA. Petrie GN, et al. Among authors: smoum r. Psychopharmacology (Berl). 2019 Sep;236(9):2623-2633. doi: 10.1007/s00213-019-05237-9. Epub 2019 Apr 16. Psychopharmacology (Berl). 2019. PMID: 30993360
39 results