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From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).
Aurelio L, Scullino CV, Pitman MR, Sexton A, Oliver V, Davies L, Rebello RJ, Furic L, Creek DJ, Pitson SM, Flynn BL. Aurelio L, et al. Among authors: pitson sm. J Med Chem. 2016 Feb 11;59(3):965-84. doi: 10.1021/acs.jmedchem.5b01439. Epub 2016 Feb 3. J Med Chem. 2016. PMID: 26780304
Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition.
Savira F, Magaye R, Scullino CV, Flynn BL, Pitson SM, Anderson D, Creek DJ, Hua Y, Xiong X, Huang L, Liew D, Reid C, Kaye D, Kompa AR, Wang BH. Savira F, et al. Among authors: pitson sm. Toxicol Lett. 2021 Oct 10;350:133-142. doi: 10.1016/j.toxlet.2021.07.012. Epub 2021 Jul 22. Toxicol Lett. 2021. PMID: 34303789
TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1.
Etemadi N, Chopin M, Anderton H, Tanzer MC, Rickard JA, Abeysekera W, Hall C, Spall SK, Wang B, Xiong Y, Hla T, Pitson SM, Bonder CS, Wong WW, Ernst M, Smyth GK, Vaux DL, Nutt SL, Nachbur U, Silke J. Etemadi N, et al. Among authors: pitson sm. Elife. 2015 Dec 23;4:e10592. doi: 10.7554/eLife.10592. Elife. 2015. PMID: 26701909 Free PMC article.
165 results