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From Sphingosine Kinase to Dihydroceramide Desaturase: A Structure-Activity Relationship (SAR) Study of the Enzyme Inhibitory and Anticancer Activity of 4-((4-(4-Chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II).
Aurelio L, Scullino CV, Pitman MR, Sexton A, Oliver V, Davies L, Rebello RJ, Furic L, Creek DJ, Pitson SM, Flynn BL. Aurelio L, et al. Among authors: flynn bl. J Med Chem. 2016 Feb 11;59(3):965-84. doi: 10.1021/acs.jmedchem.5b01439. Epub 2016 Feb 3. J Med Chem. 2016. PMID: 26780304
The role of dihydrosphingolipids in disease.
Magaye RR, Savira F, Hua Y, Kelly DJ, Reid C, Flynn B, Liew D, Wang BH. Magaye RR, et al. Cell Mol Life Sci. 2019 Mar;76(6):1107-1134. doi: 10.1007/s00018-018-2984-8. Epub 2018 Dec 6. Cell Mol Life Sci. 2019. PMID: 30523364 Free PMC article. Review.
Sphingolipid imbalance and inflammatory effects induced by uremic toxins in heart and kidney cells are reversed by dihydroceramide desaturase 1 inhibition.
Savira F, Magaye R, Scullino CV, Flynn BL, Pitson SM, Anderson D, Creek DJ, Hua Y, Xiong X, Huang L, Liew D, Reid C, Kaye D, Kompa AR, Wang BH. Savira F, et al. Among authors: flynn bl. Toxicol Lett. 2021 Oct 10;350:133-142. doi: 10.1016/j.toxlet.2021.07.012. Epub 2021 Jul 22. Toxicol Lett. 2021. PMID: 34303789
64 results