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AKAP150 contributes to enhanced vascular tone by facilitating large-conductance Ca2+-activated K+ channel remodeling in hyperglycemia and diabetes mellitus.
Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF. Nystoriak MA, et al. Circ Res. 2014 Feb 14;114(4):607-15. doi: 10.1161/CIRCRESAHA.114.302168. Epub 2013 Dec 9. Circ Res. 2014. PMID: 24323672 Free PMC article.
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.
Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF. Nystoriak MA, et al. Sci Signal. 2017 Jan 24;10(463):eaaf9647. doi: 10.1126/scisignal.aaf9647. Sci Signal. 2017. PMID: 28119464 Free PMC article.
Calcium Channels in Vascular Smooth Muscle.
Ghosh D, Syed AU, Prada MP, Nystoriak MA, Santana LF, Nieves-Cintrón M, Navedo MF. Ghosh D, et al. Adv Pharmacol. 2017;78:49-87. doi: 10.1016/bs.apha.2016.08.002. Epub 2016 Oct 14. Adv Pharmacol. 2017. PMID: 28212803 Free PMC article. Review.
49 results