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Runcaciguat, a novel soluble guanylate cyclase activator, shows renoprotection in hypertensive, diabetic, and metabolic preclinical models of chronic kidney disease.
Bénardeau A, Kahnert A, Schomber T, Meyer J, Pavkovic M, Kretschmer A, Lawrenz B, Hartmann E, Mathar I, Hueser J, Kraehling JR, Eitner F, Hahn MG, Stasch JP, Sandner P. Bénardeau A, et al. Among authors: stasch jp. Naunyn Schmiedebergs Arch Pharmacol. 2021 Dec;394(12):2363-2379. doi: 10.1007/s00210-021-02149-4. Epub 2021 Sep 22. Naunyn Schmiedebergs Arch Pharmacol. 2021. PMID: 34550407 Free PMC article.
NO-independent regulatory site on soluble guanylate cyclase.
Stasch JP, Becker EM, Alonso-Alija C, Apeler H, Dembowsky K, Feurer A, Gerzer R, Minuth T, Perzborn E, Pleiss U, Schröder H, Schroeder W, Stahl E, Steinke W, Straub A, Schramm M. Stasch JP, et al. Nature. 2001 Mar 8;410(6825):212-5. doi: 10.1038/35065611. Nature. 2001. PMID: 11242081
NO-independent stimulators of soluble guanylate cyclase.
Straub A, Stasch JP, Alonso-Alija C, Benet-Buchholz J, Ducke B, Feurer A, Fürstner C. Straub A, et al. Among authors: stasch jp. Bioorg Med Chem Lett. 2001 Mar 26;11(6):781-4. doi: 10.1016/s0960-894x(01)00073-7. Bioorg Med Chem Lett. 2001. PMID: 11277519
NO- and haem-independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle.
Stasch JP, Schmidt P, Alonso-Alija C, Apeler H, Dembowsky K, Haerter M, Heil M, Minuth T, Perzborn E, Pleiss U, Schramm M, Schroeder W, Schröder H, Stahl E, Steinke W, Wunder F. Stasch JP, et al. Br J Pharmacol. 2002 Jul;136(5):773-83. doi: 10.1038/sj.bjp.0704778. Br J Pharmacol. 2002. PMID: 12086987 Free PMC article.
Preparation of heme-free soluble guanylate cyclase.
Schmidt P, Schramm M, Schröder H, Stasch JP. Schmidt P, et al. Among authors: stasch jp. Protein Expr Purif. 2003 Sep;31(1):42-6. doi: 10.1016/s1046-5928(03)00142-6. Protein Expr Purif. 2003. PMID: 12963339
200 results