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Antiepileptic Drug-Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator-Activated Receptor α and Peroxisome Proliferator-Activated Receptor γ Coactivator 1α-Dependent Gene Expression to Increase Blood Triglyceride Levels.
Shizu R, Otsuka Y, Ezaki K, Ishii C, Arakawa S, Amaike Y, Abe T, Hosaka T, Sasaki T, Kanno Y, Miyata M, Yamazoe Y, Yoshinari K. Shizu R, et al. Among authors: kanno y. Mol Pharmacol. 2020 Nov;98(5):634-647. doi: 10.1124/molpharm.120.000103. Epub 2020 Sep 5. Mol Pharmacol. 2020. PMID: 32892155
Helix 12 stabilization contributes to basal transcriptional activity of PXR.
Shizu R, Nishiguchi H, Tashiro S, Sato T, Sugawara A, Kanno Y, Hosaka T, Sasaki T, Yoshinari K. Shizu R, et al. Among authors: kanno y. J Biol Chem. 2021 Sep;297(3):100978. doi: 10.1016/j.jbc.2021.100978. Epub 2021 Jul 17. J Biol Chem. 2021. PMID: 34284062 Free PMC article.
Activation of the aryl hydrocarbon receptor by 3-methylcholanthrene, but not by indirubin, suppresses mammosphere formation via downregulation of CDC20 expression in breast cancer cells.
Yamashita N, Yoshizuka A, Kase A, Ozawa M, Taga C, Sanada N, Kanno Y, Nemoto K, Kizu R. Yamashita N, et al. Among authors: kanno y. Biochem Biophys Res Commun. 2021 Sep 17;570:131-136. doi: 10.1016/j.bbrc.2021.07.047. Epub 2021 Jul 17. Biochem Biophys Res Commun. 2021. PMID: 34280616
1,108 results