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Farnesoid X receptor agonist for the treatment of chronic hepatitis B: A safety study.
Erken R, Andre P, Roy E, Kootstra N, Barzic N, Girma H, Laveille C, Radreau-Pierini P, Darteil R, Vonderscher J, Scalfaro P, Tangkijvanich P, Flisiak R, Reesink H. Erken R, et al. Among authors: scalfaro p. J Viral Hepat. 2021 Dec;28(12):1690-1698. doi: 10.1111/jvh.13608. Epub 2021 Sep 29. J Viral Hepat. 2021. PMID: 34467593 Free PMC article. Clinical Trial.
The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naïve hepatitis C patients.
Flisiak R, Feinman SV, Jablkowski M, Horban A, Kryczka W, Pawlowska M, Heathcote JE, Mazzella G, Vandelli C, Nicolas-Métral V, Grosgurin P, Liz JS, Scalfaro P, Porchet H, Crabbé R. Flisiak R, et al. Among authors: scalfaro p. Hepatology. 2009 May;49(5):1460-8. doi: 10.1002/hep.22835. Hepatology. 2009. PMID: 19353740 Clinical Trial.
The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.
Flisiak R, Horban A, Gallay P, Bobardt M, Selvarajah S, Wiercinska-Drapalo A, Siwak E, Cielniak I, Higersberger J, Kierkus J, Aeschlimann C, Grosgurin P, Nicolas-Métral V, Dumont JM, Porchet H, Crabbé R, Scalfaro P. Flisiak R, et al. Among authors: scalfaro p. Hepatology. 2008 Mar;47(3):817-26. doi: 10.1002/hep.22131. Hepatology. 2008. PMID: 18302285 Clinical Trial.
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent.
Ptak RG, Gallay PA, Jochmans D, Halestrap AP, Ruegg UT, Pallansch LA, Bobardt MD, de Béthune MP, Neyts J, De Clercq E, Dumont JM, Scalfaro P, Besseghir K, Wenger RM, Rosenwirth B. Ptak RG, et al. Among authors: scalfaro p. Antimicrob Agents Chemother. 2008 Apr;52(4):1302-17. doi: 10.1128/AAC.01324-07. Epub 2008 Jan 22. Antimicrob Agents Chemother. 2008. PMID: 18212100 Free PMC article.
Naturally occurring capsid substitutions render HIV-1 cyclophilin A independent in human cells and TRIM-cyclophilin-resistant in Owl monkey cells.
Chatterji U, Bobardt MD, Stanfield R, Ptak RG, Pallansch LA, Ward PA, Jones MJ, Stoddart CA, Scalfaro P, Dumont JM, Besseghir K, Rosenwirth B, Gallay PA. Chatterji U, et al. Among authors: scalfaro p. J Biol Chem. 2005 Dec 2;280(48):40293-300. doi: 10.1074/jbc.M506314200. Epub 2005 Sep 30. J Biol Chem. 2005. PMID: 16199531 Free article.
Inhibition of mitochondrial permeability transition improves functional recovery and reduces mortality following acute myocardial infarction in mice.
Gomez L, Thibault H, Gharib A, Dumont JM, Vuagniaux G, Scalfaro P, Derumeaux G, Ovize M. Gomez L, et al. Among authors: scalfaro p. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1654-61. doi: 10.1152/ajpheart.01378.2006. Epub 2007 Jun 8. Am J Physiol Heart Circ Physiol. 2007. PMID: 17557911 Free article.
Hepatic and renal improvements with FXR agonist vonafexor in individuals with suspected fibrotic NASH.
Ratziu V, Harrison SA, Loustaud-Ratti V, Bureau C, Lawitz E, Abdelmalek M, Alkhouri N, Francque S, Girma H, Darteil R, Couchoux H, Wolf M, Sanyal A, Vonderscher J, Scalfaro P. Ratziu V, et al. Among authors: scalfaro p. J Hepatol. 2023 Mar;78(3):479-492. doi: 10.1016/j.jhep.2022.10.023. Epub 2022 Nov 9. J Hepatol. 2023. PMID: 36334688 Free article. Clinical Trial.
25 results