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Mitochondria-targeted inhibitors of the human SIRT3 lysine deacetylase.
Troelsen KS, Bæk M, Nielsen AL, Madsen AS, Rajabi N, Olsen CA. Troelsen KS, et al. Among authors: nielsen al. RSC Chem Biol. 2021 Feb 1;2(2):627-635. doi: 10.1039/d0cb00216j. eCollection 2021 Apr 1. RSC Chem Biol. 2021. PMID: 34458804 Free PMC article.
Finding the gas pedal on a slow sirtuin.
Nielsen AL, Olsen CA. Nielsen AL, et al. J Biol Chem. 2020 Jan 31;295(5):1400-1401. doi: 10.1074/jbc.H120.012534. J Biol Chem. 2020. PMID: 32005646 Free PMC article.
Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of α-tubulin acetylation and inhibition of breast cancer cell migration.
Nielsen AL, Rajabi N, Kudo N, Lundø K, Moreno-Yruela C, Bæk M, Fontenas M, Lucidi A, Madsen AS, Yoshida M, Olsen CA. Nielsen AL, et al. RSC Chem Biol. 2021 Jan 14;2(2):612-626. doi: 10.1039/d0cb00036a. eCollection 2021 Apr 1. RSC Chem Biol. 2021. PMID: 34458803 Free PMC article.
Class I histone deacetylases (HDAC1-3) are histone lysine delactylases.
Moreno-Yruela C, Zhang D, Wei W, Bæk M, Liu W, Gao J, Danková D, Nielsen AL, Bolding JE, Yang L, Jameson ST, Wong J, Olsen CA, Zhao Y. Moreno-Yruela C, et al. Among authors: nielsen al. Sci Adv. 2022 Jan 21;8(3):eabi6696. doi: 10.1126/sciadv.abi6696. Epub 2022 Jan 19. Sci Adv. 2022. PMID: 35044827 Free PMC article.
Substrates and Cyclic Peptide Inhibitors of the Oligonucleotide-Activated Sirtuin 7.
Bolding JE, Nielsen AL, Jensen I, Hansen TN, Ryberg LA, Jameson ST, Harris P, Peters GHJ, Denu JM, Rogers JM, Olsen CA. Bolding JE, et al. Among authors: nielsen al. Angew Chem Int Ed Engl. 2023 Dec 4;62(49):e202314597. doi: 10.1002/anie.202314597. Epub 2023 Nov 7. Angew Chem Int Ed Engl. 2023. PMID: 37873919
Recent achievements in developing selective Gq inhibitors.
Zhang H, Nielsen AL, Strømgaard K. Zhang H, et al. Among authors: nielsen al. Med Res Rev. 2020 Jan;40(1):135-157. doi: 10.1002/med.21598. Epub 2019 Jun 19. Med Res Rev. 2020. PMID: 31218731 Review.
336 results