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Structural Insights into the Unique Modes of Relaxin-Binding and Tethered-Agonist Mediated Activation of RXFP1 and RXFP2.
Sethi A, Bruell S, Ryan T, Yan F, Tanipour MH, Mok YF, Draper-Joyce C, Khandokar Y, Metcalfe RD, Griffin MDW, Scott DJ, Hossain MA, Petrie EJ, Bathgate RAD, Gooley PR. Sethi A, et al. Among authors: draper joyce c. J Mol Biol. 2021 Oct 15;433(21):167217. doi: 10.1016/j.jmb.2021.167217. Epub 2021 Aug 26. J Mol Biol. 2021. PMID: 34454945
Strength in numbers-an arrestin interaction code.
Draper-Joyce CJ, Christopoulos A. Draper-Joyce CJ, et al. Nat Struct Mol Biol. 2018 Jun;25(6):437-439. doi: 10.1038/s41594-018-0077-x. Nat Struct Mol Biol. 2018. PMID: 29872226 No abstract available.
A new mechanism of allostery in a G protein-coupled receptor dimer.
Lane JR, Donthamsetti P, Shonberg J, Draper-Joyce CJ, Dentry S, Michino M, Shi L, López L, Scammells PJ, Capuano B, Sexton PM, Javitch JA, Christopoulos A. Lane JR, et al. Nat Chem Biol. 2014 Sep;10(9):745-52. doi: 10.1038/nchembio.1593. Epub 2014 Aug 10. Nat Chem Biol. 2014. PMID: 25108820 Free PMC article.
Recent advances in the determination of G protein-coupled receptor structures.
Thal DM, Vuckovic Z, Draper-Joyce CJ, Liang YL, Glukhova A, Christopoulos A, Sexton PM. Thal DM, et al. Among authors: draper joyce cj. Curr Opin Struct Biol. 2018 Aug;51:28-34. doi: 10.1016/j.sbi.2018.03.002. Epub 2018 Mar 13. Curr Opin Struct Biol. 2018. PMID: 29547818 Review.
Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia.
Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, White PJ, Scammells P, May LT, Sexton PM, Danev R, Miao Y, Glukhova A, Imlach WL, Christopoulos A. Draper-Joyce CJ, et al. Nature. 2021 Sep;597(7877):571-576. doi: 10.1038/s41586-021-03897-2. Epub 2021 Sep 8. Nature. 2021. PMID: 34497422 Free PMC article.
Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole.
Klein Herenbrink C, Verma R, Lim HD, Kopinathan A, Keen A, Shonberg J, Draper-Joyce CJ, Scammells PJ, Christopoulos A, Javitch JA, Capuano B, Shi L, Lane JR. Klein Herenbrink C, et al. Among authors: draper joyce cj. ACS Chem Biol. 2019 Aug 16;14(8):1780-1792. doi: 10.1021/acschembio.9b00342. Epub 2019 Aug 5. ACS Chem Biol. 2019. PMID: 31339684 Free PMC article.
Structure-activity study of N-((trans)-4-(2-(7-cyano-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)cyclohexyl)-1H-indole-2-carboxamide (SB269652), a bitopic ligand that acts as a negative allosteric modulator of the dopamine D2 receptor.
Shonberg J, Draper-Joyce C, Mistry SN, Christopoulos A, Scammells PJ, Lane JR, Capuano B. Shonberg J, et al. J Med Chem. 2015 Jul 9;58(13):5287-307. doi: 10.1021/acs.jmedchem.5b00581. Epub 2015 Jun 24. J Med Chem. 2015. PMID: 26052807 Free article.
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