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Safety and immunogenicity of intramuscularly administered CS6 subunit vaccine with a modified heat-labile enterotoxin from enterotoxigenic Escherichia coli.
Lee T, Gutiérrez RL, Maciel M, Poole S, Testa KJ, Trop S, Duplessis C, Lane A, Riddle MS, Hamer M, Alcala A, Prouty M, Maier N, Erdem R, Louis Bourgeois A, Porter CK. Lee T, et al. Among authors: poole s. Vaccine. 2021 Sep 15;39(39):5548-5556. doi: 10.1016/j.vaccine.2021.08.032. Epub 2021 Aug 18. Vaccine. 2021. PMID: 34419306 Free PMC article. Clinical Trial.
Evaluation of the immunogenicity and protective efficacy of a recombinant CS6-based ETEC vaccine in an Aotus nancymaae CS6 + ETEC challenge model.
Ramakrishnan A, Joseph SS, Reynolds ND, Poncet D, Maciel M Jr, Nunez G, Espinoza N, Nieto M, Castillo R, Royal JM, Poole S, McVeigh A, Rollenhagen JE, Heinrichs J, Prouty MG, Simons MP, Renauld-Mongénie G, Savarino SJ. Ramakrishnan A, et al. Among authors: poole s. Vaccine. 2021 Jan 15;39(3):487-494. doi: 10.1016/j.vaccine.2020.12.034. Epub 2020 Dec 21. Vaccine. 2021. PMID: 33357957
Oral delivery of Hyperimmune bovine serum antibodies against CS6-expressing enterotoxigenic Escherichia coli as a prophylactic against diarrhea.
Talaat KR, Porter CK, Bourgeois AL, Lee TK, Duplessis CA, Maciel M Jr, Gutierrez RL, DeNearing B, Adjoodani B, Adkinson R, Testa KJ, Feijoo B, Alcala AN, Brubaker J, Beselman A, Chakraborty S, Sack D, Halpern J, Trop S, Wu H, Jiao J, Sullivan E, Riddle MS, Joseph SS, Poole ST, Prouty MG. Talaat KR, et al. Among authors: poole st. Gut Microbes. 2020 Nov 9;12(1):1732852. doi: 10.1080/19490976.2020.1732852. Epub 2020 Mar 13. Gut Microbes. 2020. PMID: 32167011 Free PMC article. Clinical Trial.
Evaluation of a conjugate vaccine platform against enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni and Shigella.
Laird RM, Ma Z, Dorabawila N, Pequegnat B, Omari E, Liu Y, Maue AC, Poole ST, Maciel M, Satish K, Gariepy CL, Schumack NM, McVeigh AL, Poly F, Ewing CP, Prouty MG, Monteiro MA, Savarino SJ, Guerry P. Laird RM, et al. Vaccine. 2018 Oct 29;36(45):6695-6702. doi: 10.1016/j.vaccine.2018.09.052. Epub 2018 Sep 27. Vaccine. 2018. PMID: 30269917 Free PMC article.
Intradermal or Sublingual Delivery and Heat-Labile Enterotoxin Proteins Shape Immunologic Responses to a CFA/I Fimbria-Derived Subunit Antigen Vaccine against Enterotoxigenic Escherichia coli.
Maciel M Jr, Bauer D, Baudier RL, Bitoun J, Clements JD, Poole ST, Smith MA, Kaminski RW, Savarino SJ, Norton EB. Maciel M Jr, et al. Infect Immun. 2019 Oct 18;87(11):e00460-19. doi: 10.1128/IAI.00460-19. Print 2019 Nov. Infect Immun. 2019. PMID: 31427449 Free PMC article.
Evaluation of transcutaneous immunization as a delivery route for an enterotoxigenic E. coli adhesin-based vaccine with CfaE, the colonization factor antigen 1 (CFA/I) tip adhesin.
Rollenhagen JE, Woods CM, O'Dowd A, Poole ST, Tian JH, Guebre-Xabier M, Ellingsworth L, Prouty MG, Glenn G, Savarino SJ. Rollenhagen JE, et al. Vaccine. 2019 Sep 30;37(42):6134-6138. doi: 10.1016/j.vaccine.2019.08.057. Epub 2019 Sep 3. Vaccine. 2019. PMID: 31492474 Free article.
A first in human clinical trial assessing the safety and immunogenicity of transcutaneously delivered enterotoxigenic Escherichia coli fimbrial tip adhesin with heat-labile enterotoxin with mutation R192G.
Riddle MS, Maciel M Jr, Porter CK, Poole ST, Gutierrez RL, Gormley R, Laird RM, Sebeny PJ, Dori KE, Greenleaf ME, Hoq F, Turiansky GW, Jarell A, Hawk D, Tribble D, Savarino SJ. Riddle MS, et al. Among authors: poole st. Vaccine. 2020 Oct 21;38(45):7040-7048. doi: 10.1016/j.vaccine.2020.09.025. Epub 2020 Sep 22. Vaccine. 2020. PMID: 32978003
580 results