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Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells.
Sajith AM, Narasimhamurthy KH, Shanmugam MK, Rangappa S, Chandra Nayak S, Chinnathambi A, Awad Alahmadi T, Ali Alharbi S, Haridas KR, Reddy EK, Savitha B, Mohan CD, Rangappa KS. Sajith AM, et al. Among authors: shanmugam mk. Bioorg Med Chem Lett. 2021 Oct 15;50:128332. doi: 10.1016/j.bmcl.2021.128332. Epub 2021 Aug 19. Bioorg Med Chem Lett. 2021. PMID: 34418571
γ-Tocotrienol is a novel inhibitor of constitutive and inducible STAT3 signalling pathway in human hepatocellular carcinoma: potential role as an antiproliferative, pro-apoptotic and chemosensitizing agent.
Rajendran P, Li F, Manu KA, Shanmugam MK, Loo SY, Kumar AP, Sethi G. Rajendran P, et al. Among authors: shanmugam mk. Br J Pharmacol. 2011 May;163(2):283-98. doi: 10.1111/j.1476-5381.2010.01187.x. Br J Pharmacol. 2011. PMID: 21198544 Free PMC article.
Celastrol inhibits proliferation and induces chemosensitization through down-regulation of NF-κB and STAT3 regulated gene products in multiple myeloma cells.
Kannaiyan R, Hay HS, Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Sharma A, Kumar AP, Chng WJ, Sethi G. Kannaiyan R, et al. Among authors: shanmugam mk. Br J Pharmacol. 2011 Nov;164(5):1506-21. doi: 10.1111/j.1476-5381.2011.01449.x. Br J Pharmacol. 2011. PMID: 21506956 Free PMC article.
Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4.
Manu KA, Shanmugam MK, Rajendran P, Li F, Ramachandran L, Hay HS, Kannaiyan R, Swamy SN, Vali S, Kapoor S, Ramesh B, Bist P, Koay ES, Lim LH, Ahn KS, Kumar AP, Sethi G. Manu KA, et al. Among authors: shanmugam mk. Mol Cancer. 2011 Sep 1;10:107. doi: 10.1186/1476-4598-10-107. Mol Cancer. 2011. PMID: 21880153 Free PMC article.
Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade in vitro and in vivo.
Rajendran P, Li F, Shanmugam MK, Kannaiyan R, Goh JN, Wong KF, Wang W, Khin E, Tergaonkar V, Kumar AP, Luk JM, Sethi G. Rajendran P, et al. Among authors: shanmugam mk. Cancer Prev Res (Phila). 2012 Apr;5(4):631-43. doi: 10.1158/1940-6207.CAPR-11-0420. Epub 2012 Feb 27. Cancer Prev Res (Phila). 2012. PMID: 22369852
Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.
Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, Ashktorab H, Tan P, Ahn KS, Yap CW, Kumar AP, Sethi G. Ramachandran L, et al. Among authors: shanmugam mk. J Biol Chem. 2012 Nov 2;287(45):38028-40. doi: 10.1074/jbc.M112.388702. Epub 2012 Sep 19. J Biol Chem. 2012. PMID: 22992727 Free PMC article.
114 results