Rosen N - Search Results

1

Defining the therapeutic selective dependencies for distinct subtypes of PI3K pathway-altered prostate cancers.

Mao N, Zhang Z, Lee YS, Choi D, Rivera AA, Li D, Lee C, Haywood S, Chen X, Chang Q, Xu G, Chen HA, de Stanchina E, Sawyers C, Rosen N, Hsieh AC, Chen Y, Carver BS. Mao N, et al. Among authors: rosen n. Nat Commun. 2021 Aug 20;12(1):5053. doi: 10.1038/s41467-021-25341-9. Nat Commun. 2021. PMID: 34417459 Free PMC article.

2

A novel pyridopyrimidine inhibitor of abl kinase is a picomolar inhibitor of Bcr-abl-driven K562 cells and is effective against STI571-resistant Bcr-abl mutants.

Huron DR, Gorre ME, Kraker AJ, Sawyers CL, Rosen N, Moasser MM. Huron DR, et al. Among authors: rosen n. Clin Cancer Res. 2003 Apr;9(4):1267-73. Clin Cancer Res. 2003. PMID: 12684394

3

BRAF mutation predicts sensitivity to MEK inhibition.

Solit DB, Garraway LA, Pratilas CA, Sawai A, Getz G, Basso A, Ye Q, Lobo JM, She Y, Osman I, Golub TR, Sebolt-Leopold J, Sellers WR, Rosen N. Solit DB, et al. Among authors: rosen n. Nature. 2006 Jan 19;439(7074):358-62. doi: 10.1038/nature04304. Epub 2005 Nov 6. Nature. 2006. PMID: 16273091 Free PMC article.

4

Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.

She QB, Chandarlapaty S, Ye Q, Lobo J, Haskell KM, Leander KR, DeFeo-Jones D, Huber HE, Rosen N. She QB, et al. Among authors: rosen n. PLoS One. 2008 Aug 26;3(8):e3065. doi: 10.1371/journal.pone.0003065. PLoS One. 2008. PMID: 18725974 Free PMC article.

5

Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer.

Welsbie DS, Xu J, Chen Y, Borsu L, Scher HI, Rosen N, Sawyers CL. Welsbie DS, et al. Among authors: rosen n. Cancer Res. 2009 Feb 1;69(3):958-66. doi: 10.1158/0008-5472.CAN-08-2216. Epub 2009 Jan 27. Cancer Res. 2009. PMID: 19176386 Free PMC article.

6

RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.

Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. Poulikakos PI, et al. Among authors: rosen n. Nature. 2010 Mar 18;464(7287):427-30. doi: 10.1038/nature08902. Nature. 2010. PMID: 20179705 Free PMC article.

7

4E-BP1 is a key effector of the oncogenic activation of the AKT and ERK signaling pathways that integrates their function in tumors.

She QB, Halilovic E, Ye Q, Zhen W, Shirasawa S, Sasazuki T, Solit DB, Rosen N. She QB, et al. Among authors: rosen n. Cancer Cell. 2010 Jul 13;18(1):39-51. doi: 10.1016/j.ccr.2010.05.023. Cancer Cell. 2010. PMID: 20609351 Free PMC article.

8

AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity.

Chandarlapaty S, Sawai A, Scaltriti M, Rodrik-Outmezguine V, Grbovic-Huezo O, Serra V, Majumder PK, Baselga J, Rosen N. Chandarlapaty S, et al. Among authors: rosen n. Cancer Cell. 2011 Jan 18;19(1):58-71. doi: 10.1016/j.ccr.2010.10.031. Epub 2011 Jan 6. Cancer Cell. 2011. PMID: 21215704 Free PMC article.

9

Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer.

Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, Scardino PT, Rosen N, Sawyers CL. Carver BS, et al. Among authors: rosen n. Cancer Cell. 2011 May 17;19(5):575-86. doi: 10.1016/j.ccr.2011.04.008. Cancer Cell. 2011. PMID: 21575859 Free PMC article.

10

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E).

Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, Shi H, Atefi M, Titz B, Gabay MT, Salton M, Dahlman KB, Tadi M, Wargo JA, Flaherty KT, Kelley MC, Misteli T, Chapman PB, Sosman JA, Graeber TG, Ribas A, Lo RS, Rosen N, Solit DB. Poulikakos PI, et al. Among authors: rosen n. Nature. 2011 Nov 23;480(7377):387-90. doi: 10.1038/nature10662. Nature. 2011. PMID: 22113612 Free PMC article.

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