Orr HT - Search Results

1

Consensus Paper: Strengths and Weaknesses of Animal Models of Spinocerebellar Ataxias and Their Clinical Implications.

Cendelin J, Cvetanovic M, Gandelman M, Hirai H, Orr HT, Pulst SM, Strupp M, Tichanek F, Tuma J, Manto M. Cendelin J, et al. Among authors: orr ht. Cerebellum. 2022 Jun;21(3):452-481. doi: 10.1007/s12311-021-01311-1. Epub 2021 Aug 10. Cerebellum. 2022. PMID: 34378174 Free PMC article.

2

Cholecystokinin 1 receptor activation restores normal mTORC1 signaling and is protective to Purkinje cells of SCA mice.

Wozniak EAL, Chen Z, Paul S, Yang P, Figueroa KP, Friedrich J, Tschumperlin T, Berken M, Ingram M, Henzler C, Pulst SM, Orr HT. Wozniak EAL, et al. Among authors: orr ht. Cell Rep. 2021 Oct 12;37(2):109831. doi: 10.1016/j.celrep.2021.109831. Cell Rep. 2021. PMID: 34644575 Free PMC article.

3

Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1.

Cvetanovic M, Ingram M, Orr H, Opal P. Cvetanovic M, et al. Neuroscience. 2015 Mar 19;289:289-99. doi: 10.1016/j.neuroscience.2015.01.003. Epub 2015 Jan 14. Neuroscience. 2015. PMID: 25595967 Free PMC article.

4

Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1.

Chopra R, Bushart DD, Cooper JP, Yellajoshyula D, Morrison LM, Huang H, Handler HP, Man LJ, Dansithong W, Scoles DR, Pulst SM, Orr HT, Shakkottai VG. Chopra R, et al. Among authors: orr ht. Hum Mol Genet. 2020 Nov 25;29(19):3249-3265. doi: 10.1093/hmg/ddaa212. Hum Mol Genet. 2020. PMID: 32964235 Free PMC article.

5

Targeting inhibitory cerebellar circuitry to alleviate behavioral deficits in a mouse model for studying idiopathic autism.

Chao OY, Marron Fernandez de Velasco E, Pathak SS, Maitra S, Zhang H, Duvick L, Wickman K, Orr HT, Hirai H, Yang YM. Chao OY, et al. Among authors: orr ht. Neuropsychopharmacology. 2020 Jun;45(7):1159-1170. doi: 10.1038/s41386-020-0656-5. Epub 2020 Mar 16. Neuropsychopharmacology. 2020. PMID: 32179875 Free PMC article.

6

Genetically engineered mouse models of the trinucleotide-repeat spinocerebellar ataxias.

Ingram MA, Orr HT, Clark HB. Ingram MA, et al. Among authors: orr ht. Brain Res Bull. 2012 May 1;88(1):33-42. doi: 10.1016/j.brainresbull.2011.07.016. Epub 2011 Jul 23. Brain Res Bull. 2012. PMID: 21810454 Free PMC article. Review.

7

Polyglutamine spinocerebellar ataxias - from genes to potential treatments.

Paulson HL, Shakkottai VG, Clark HB, Orr HT. Paulson HL, et al. Among authors: orr ht. Nat Rev Neurosci. 2017 Oct;18(10):613-626. doi: 10.1038/nrn.2017.92. Epub 2017 Aug 17. Nat Rev Neurosci. 2017. PMID: 28855740 Free PMC article. Review.

8

Cholecystokinin Activation of Cholecystokinin 1 Receptors: a Purkinje Cell Neuroprotective Pathway.

Orr HT. Orr HT. Cerebellum. 2023 Aug;22(4):756-760. doi: 10.1007/s12311-022-01428-x. Epub 2022 Jun 23. Cerebellum. 2023. PMID: 35733029 Free PMC article. Review.

9

Emerging pathogenic pathways in the spinocerebellar ataxias.

Carlson KM, Andresen JM, Orr HT. Carlson KM, et al. Among authors: orr ht. Curr Opin Genet Dev. 2009 Jun;19(3):247-53. doi: 10.1016/j.gde.2009.02.009. Epub 2009 Apr 1. Curr Opin Genet Dev. 2009. PMID: 19345087 Free PMC article. Review.

10

Spinocerebellar ataxia type 1--modeling the pathogenesis of a polyglutamine neurodegenerative disorder in transgenic mice.

Clark HB, Orr HT. Clark HB, et al. Among authors: orr ht. J Neuropathol Exp Neurol. 2000 Apr;59(4):265-70. doi: 10.1093/jnen/59.4.265. J Neuropathol Exp Neurol. 2000. PMID: 10759181 Review.

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