Wu J - Search Results

1

Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics.

Lorenz R, Wu J, Herberg FW, Taylor SS, Engh RA. Lorenz R, et al. Among authors: wu j. Biochemistry. 2021 Nov 23;60(46):3470-3484. doi: 10.1021/acs.biochem.1c00359. Epub 2021 Aug 9. Biochemistry. 2021. PMID: 34370450

2

Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure.

Akamine P, Madhusudan, Wu J, Xuong NH, Ten Eyck LF, Taylor SS. Akamine P, et al. Among authors: wu j. J Mol Biol. 2003 Mar 14;327(1):159-71. doi: 10.1016/s0022-2836(02)01446-8. J Mol Biol. 2003. PMID: 12614615

3

PKA: a portrait of protein kinase dynamics.

Taylor SS, Yang J, Wu J, Haste NM, Radzio-Andzelm E, Anand G. Taylor SS, et al. Among authors: wu j. Biochim Biophys Acta. 2004 Mar 11;1697(1-2):259-69. doi: 10.1016/j.bbapap.2003.11.029. Biochim Biophys Acta. 2004. PMID: 15023366 Review.

4

Crystal structures of RIalpha subunit of cyclic adenosine 5'-monophosphate (cAMP)-dependent protein kinase complexed with (Rp)-adenosine 3',5'-cyclic monophosphothioate and (Sp)-adenosine 3',5'-cyclic monophosphothioate, the phosphothioate analogues of cAMP.

Wu J, Jones JM, Nguyen-Huu X, Ten Eyck LF, Taylor SS. Wu J, et al. Biochemistry. 2004 Jun 1;43(21):6620-9. doi: 10.1021/bi0302503. Biochemistry. 2004. PMID: 15157095

5

RIalpha subunit of PKA: a cAMP-free structure reveals a hydrophobic capping mechanism for docking cAMP into site B.

Wu J, Brown S, Xuong NH, Taylor SS. Wu J, et al. Structure. 2004 Jun;12(6):1057-65. doi: 10.1016/j.str.2004.03.022. Structure. 2004. PMID: 15274925 Free article.

6

Dynamics of signaling by PKA.

Taylor SS, Kim C, Vigil D, Haste NM, Yang J, Wu J, Anand GS. Taylor SS, et al. Among authors: wu j. Biochim Biophys Acta. 2005 Dec 30;1754(1-2):25-37. doi: 10.1016/j.bbapap.2005.08.024. Epub 2005 Sep 22. Biochim Biophys Acta. 2005. PMID: 16214430 Review.

7

Crystal structure of the E230Q mutant of cAMP-dependent protein kinase reveals an unexpected apoenzyme conformation and an extended N-terminal A helix.

Wu J, Yang J, Kannan N, Madhusudan, Xuong NH, Ten Eyck LF, Taylor SS. Wu J, et al. Protein Sci. 2005 Nov;14(11):2871-9. doi: 10.1110/ps.051715205. Protein Sci. 2005. PMID: 16253959 Free PMC article.

8

PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity.

Wu J, Brown SH, von Daake S, Taylor SS. Wu J, et al. Science. 2007 Oct 12;318(5848):274-9. doi: 10.1126/science.1146447. Science. 2007. PMID: 17932298 Free PMC article.

9

Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.

Taylor SS, Kim C, Cheng CY, Brown SH, Wu J, Kannan N. Taylor SS, et al. Among authors: wu j. Biochim Biophys Acta. 2008 Jan;1784(1):16-26. doi: 10.1016/j.bbapap.2007.10.002. Epub 2007 Oct 12. Biochim Biophys Acta. 2008. PMID: 17996741 Free PMC article. Review.

10

Evolution of allostery in the cyclic nucleotide binding module.

Kannan N, Wu J, Anand GS, Yooseph S, Neuwald AF, Venter JC, Taylor SS. Kannan N, et al. Among authors: wu j. Genome Biol. 2007;8(12):R264. doi: 10.1186/gb-2007-8-12-r264. Genome Biol. 2007. PMID: 18076763 Free PMC article.

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