Lorenz R - Search Results

1

Drugging the Undruggable: How Isoquinolines and PKA Initiated the Era of Designed Protein Kinase Inhibitor Therapeutics.

Lorenz R, Wu J, Herberg FW, Taylor SS, Engh RA. Lorenz R, et al. Biochemistry. 2021 Nov 23;60(46):3470-3484. doi: 10.1021/acs.biochem.1c00359. Epub 2021 Aug 9. Biochemistry. 2021. PMID: 34370450

2

Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I.

Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C. Huang GY, et al. Among authors: lorenz r. Structure. 2014 Jan 7;22(1):116-24. doi: 10.1016/j.str.2013.09.021. Epub 2013 Nov 14. Structure. 2014. PMID: 24239458 Free PMC article.

3

Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).

VanSchouwen B, Selvaratnam R, Giri R, Lorenz R, Herberg FW, Kim C, Melacini G. VanSchouwen B, et al. Among authors: lorenz r. J Biol Chem. 2015 Nov 27;290(48):28631-41. doi: 10.1074/jbc.M115.685305. Epub 2015 Sep 14. J Biol Chem. 2015. PMID: 26370085 Free PMC article.

4

Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.

Kim JJ, Lorenz R, Arold ST, Reger AS, Sankaran B, Casteel DE, Herberg FW, Kim C. Kim JJ, et al. Among authors: lorenz r. Structure. 2016 May 3;24(5):710-720. doi: 10.1016/j.str.2016.03.009. Epub 2016 Apr 7. Structure. 2016. PMID: 27066748 Free PMC article.

5

cAMP-Dependent Protein Kinase and cGMP-Dependent Protein Kinase as Cyclic Nucleotide Effectors.

Lorenz R, Bertinetti D, Herberg FW. Lorenz R, et al. Handb Exp Pharmacol. 2017;238:105-122. doi: 10.1007/164_2015_36. Handb Exp Pharmacol. 2017. PMID: 27885524 Review.

6

Crystal structure of cGMP-dependent protein kinase Iβ cyclic nucleotide-binding-B domain : Rp-cGMPS complex reveals an apo-like, inactive conformation.

Campbell JC, VanSchouwen B, Lorenz R, Sankaran B, Herberg FW, Melacini G, Kim C. Campbell JC, et al. Among authors: lorenz r. FEBS Lett. 2017 Jan;591(1):221-230. doi: 10.1002/1873-3468.12505. Epub 2016 Dec 23. FEBS Lett. 2017. PMID: 27914169 Free PMC article.

7

Mutations of PKA cyclic nucleotide-binding domains reveal novel aspects of cyclic nucleotide selectivity.

Lorenz R, Moon EW, Kim JJ, Schmidt SH, Sankaran B, Pavlidis IV, Kim C, Herberg FW. Lorenz R, et al. Biochem J. 2017 Jul 6;474(14):2389-2403. doi: 10.1042/BCJ20160969. Biochem J. 2017. PMID: 28583991 Free PMC article.

8

Switching Cyclic Nucleotide-Selective Activation of Cyclic Adenosine Monophosphate-Dependent Protein Kinase Holoenzyme Reveals Distinct Roles of Tandem Cyclic Nucleotide-Binding Domains.

He D, Lorenz R, Kim C, Herberg FW, Lim CJ. He D, et al. Among authors: lorenz r. ACS Chem Biol. 2017 Dec 15;12(12):3057-3066. doi: 10.1021/acschembio.7b00732. Epub 2017 Nov 21. ACS Chem Biol. 2017. PMID: 29111666 Free PMC article.

9

Molecular Basis for Ser/Thr Specificity in PKA Signaling.

Knape MJ, Wallbott M, Burghardt NCG, Bertinetti D, Hornung J, Schmidt SH, Lorenz R, Herberg FW. Knape MJ, et al. Among authors: lorenz r. Cells. 2020 Jun 25;9(6):1548. doi: 10.3390/cells9061548. Cells. 2020. PMID: 32630525 Free PMC article.

10

LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.

Weng JH, Aoto PC, Lorenz R, Wu J, Schmidt SH, Manschwetus JT, Kaila-Sharma P, Silletti S, Mathea S, Chatterjee D, Knapp S, Herberg FW, Taylor SS. Weng JH, et al. Among authors: lorenz r. PLoS Biol. 2022 Feb 22;20(2):e3001427. doi: 10.1371/journal.pbio.3001427. eCollection 2022 Feb. PLoS Biol. 2022. PMID: 35192607 Free PMC article.

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