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The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus.
Jørgensen AS, Brandum EP, Mikkelsen JM, Orfin KA, Boilesen DR, Egerod KL, Moussouras NA, Vilhardt F, Kalinski P, Basse P, Chen YH, Yang Z, Dwinell MB, Volkman BF, Veldkamp CT, Holst PJ, Lahl K, Goth CK, Rosenkilde MM, Hjortø GM. Jørgensen AS, et al. Cell Mol Life Sci. 2021 Nov;78(21-22):6963-6978. doi: 10.1007/s00018-021-03930-7. Epub 2021 Sep 29. Cell Mol Life Sci. 2021. PMID: 34586443 Free PMC article.
Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization.
Kjær VMS, Daugvilaite V, Stepniewski TM, Madsen CM, Jørgensen AS, Bhuskute KR, Inoue A, Ulven T, Benned-Jensen T, Hjorth SA, Hjortø GM, Moo EV, Selent J, Rosenkilde MM. Kjær VMS, et al. Among authors: jorgensen as. Sci Signal. 2023 Apr 4;16(779):eabl4283. doi: 10.1126/scisignal.abl4283. Epub 2023 Apr 4. Sci Signal. 2023. PMID: 37014928
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