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Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.
Stiborová M, Moserová M, Černá V, Indra R, Dračínský M, Šulc M, Henderson CJ, Wolf CR, Schmeiser HH, Phillips DH, Frei E, Arlt VM. Stiborová M, et al. Among authors: indra r. Toxicology. 2014 Apr 6;318:1-12. doi: 10.1016/j.tox.2014.02.002. Epub 2014 Feb 14. Toxicology. 2014. PMID: 24530354
The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice.
Krais AM, Speksnijder EN, Melis JP, Indra R, Moserova M, Godschalk RW, van Schooten FJ, Seidel A, Kopka K, Schmeiser HH, Stiborova M, Phillips DH, Luijten M, Arlt VM. Krais AM, et al. Among authors: indra r. Arch Toxicol. 2016 Apr;90(4):839-51. doi: 10.1007/s00204-015-1531-8. Epub 2015 May 21. Arch Toxicol. 2016. PMID: 25995008 Free PMC article.
NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.
Stiborová M, Indra R, Moserová M, Frei E, Schmeiser HH, Kopka K, Phillips DH, Arlt VM. Stiborová M, et al. Among authors: indra r. Chem Res Toxicol. 2016 Aug 15;29(8):1325-34. doi: 10.1021/acs.chemrestox.6b00143. Epub 2016 Jul 20. Chem Res Toxicol. 2016. PMID: 27404282 Free PMC article.
Induced expression of microsomal cytochrome b5 determined at mRNA and protein levels in rats exposed to ellipticine, benzo[a]pyrene, and 1-phenylazo-2-naphthol (Sudan I).
Stiborová M, Moserová M, Mrízová I, Dračínská H, Martínek V, Indra R, Frei E, Adam V, Kizek R, Schmeiser HH, Kubáčková K, Arlt VM. Stiborová M, et al. Among authors: indra r. Monatsh Chem. 2016;147(5):897-904. doi: 10.1007/s00706-015-1636-z. Epub 2016 Jan 12. Monatsh Chem. 2016. PMID: 27110040 Free PMC article.
36 results