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Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough.
Ludbrook VJ, Hanrott KE, Kreindler JL, Marks-Konczalik JE, Bird NP, Hewens DA, Beerahee M, Behm DJ, Morice A, McGarvey L, Parker SM, Birring SS, Smith J. Ludbrook VJ, et al. Among authors: hewens da. ERJ Open Res. 2021 Aug 2;7(3):00269-2021. doi: 10.1183/23120541.00269-2021. eCollection 2021 Jul. ERJ Open Res. 2021. PMID: 34350286 Free PMC article.
An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension.
Simon MA, Hanrott K, Budd DC, Torres F, Grünig E, Escribano-Subias P, Meseguer ML, Halank M, Opitz C, Hall DA, Hewens D, Powley WM, Siederer S, Bayliffe A, Lazaar AL, Cahn A, Rosenkranz S. Simon MA, et al. Among authors: hewens d. Pulm Circ. 2022 Jan 20;12(1):e12024. doi: 10.1002/pul2.12024. eCollection 2022 Jan. Pulm Circ. 2022. PMID: 35506108 Free PMC article.