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Adaptive study design to assess effect of TRPV4 inhibition in patients with chronic cough.
ERJ Open Res. 2021 Aug 2;7(3):00269-2021. doi: 10.1183/23120541.00269-2021. eCollection 2021 Jul.
ERJ Open Res. 2021.
PMID: 34350286
Free PMC article.
Investigation of selective JAK1 inhibitor GSK2586184 for the treatment of psoriasis in a randomized placebo-controlled phase IIa study.
Ludbrook VJ, Hicks KJ, Hanrott KE, Patel JS, Binks MH, Wyres MR, Watson J, Wilson P, Simeoni M, Schifano LA, Reich K, Griffiths CE.
Ludbrook VJ, et al. Among authors: hanrott ke.
Br J Dermatol. 2016 May;174(5):985-95. doi: 10.1111/bjd.14399. Epub 2016 Apr 7.
Br J Dermatol. 2016.
PMID: 26785220
Clinical Trial.
Item in Clipboard
A randomised trial of anti-GM-CSF otilimab in severe COVID-19 pneumonia (OSCAR).
Patel J, Bass D, Beishuizen A, Bocca Ruiz X, Boughanmi H, Cahn A, Colombo H, Criner GJ, Davy K, de-Miguel-Díez J, Doreski PA, Fernandes S, François B, Gupta A, Hanrott K, Hatlen T, Inman D, Isaacs JD, Jarvis E, Kostina N, Kropotina T, Lacherade JC, Lakshminarayanan D, Martinez-Ayala P, McEvoy C, Meziani F, Monchi M, Mukherjee S, Muñoz-Bermúdez R, Neisen J, O'Shea C, Plantefeve G, Schifano L, Schwab LE, Shahid Z, Shirano M, Smith JE, Sprinz E, Summers C, Terzi N, Tidswell MA, Trefilova Y, Williamson R, Wyncoll D, Layton M.
Patel J, et al.
Eur Respir J. 2023 Feb 2;61(2):2101870. doi: 10.1183/13993003.01870-2021. Print 2023 Feb.
Eur Respir J. 2023.
PMID: 36229048
Free PMC article.
Clinical Trial.
Item in Clipboard
Effects of Recombinant Human Angiotensin-Converting Enzyme 2 on Response to Acute Hypoxia and Exercise: A Randomised, Placebo-Controlled Study.
Hall DA, Hanrott K, Badorrek P, Berliner D, Budd DC, Eames R, Powley WM, Hewens D, Siederer S, Lazaar AL, Cahn A, Hohlfeld JM.
Hall DA, et al.
Pulm Ther. 2021 Dec;7(2):487-501. doi: 10.1007/s41030-021-00164-7. Epub 2021 Jun 26.
Pulm Ther. 2021.
PMID: 34189703
Free PMC article.
Item in Clipboard
An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension.
Simon MA, Hanrott K, Budd DC, Torres F, Grünig E, Escribano-Subias P, Meseguer ML, Halank M, Opitz C, Hall DA, Hewens D, Powley WM, Siederer S, Bayliffe A, Lazaar AL, Cahn A, Rosenkranz S.
Simon MA, et al.
Pulm Circ. 2022 Jan 20;12(1):e12024. doi: 10.1002/pul2.12024. eCollection 2022 Jan.
Pulm Circ. 2022.
PMID: 35506108
Free PMC article.
Item in Clipboard
Study to Explore the Association of the Renin-Angiotensin System and Right Ventricular Function in Mechanically Ventilated Patients.
Mekontso Dessap A, Hanrott K, Powley WM, Fowler A, Bayliffe A, Bagate F, Hall DA, Lazaar AL, Budd DC, Vieillard-Baron A.
Mekontso Dessap A, et al.
J Clin Med. 2022 Jul 27;11(15):4362. doi: 10.3390/jcm11154362.
J Clin Med. 2022.
PMID: 35955981
Free PMC article.
Item in Clipboard
Differential coupling of alpha7 and non-alpha7 nicotinic acetylcholine receptors to calcium-induced calcium release and voltage-operated calcium channels in PC12 cells.
Dickinson JA, Hanrott KE, Mok MH, Kew JN, Wonnacott S.
Dickinson JA, et al. Among authors: hanrott ke.
J Neurochem. 2007 Feb;100(4):1089-96. doi: 10.1111/j.1471-4159.2006.04273.x. Epub 2006 Dec 20.
J Neurochem. 2007.
PMID: 17181555
Free article.
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