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Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of SARS-CoV-2.
Drayman N, DeMarco JK, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Han KY, O'Brien A, Tomatsidou A, Meyer B, Vignuzzi M, Missiakas D, Botten JW, Brooke CB, Lee H, Baker SC, Mounce BC, Heaton NS, Severson WE, Palmer KE, Dickinson BC, Joachimiak A, Randall G, Tay S. Drayman N, et al. Among authors: chen s. Science. 2021 Aug 20;373(6557):931-936. doi: 10.1126/science.abg5827. Epub 2021 Jul 20. Science. 2021. PMID: 34285133 Free PMC article.
Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro.
Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S. Drayman N, et al. Among authors: chen s. bioRxiv [Preprint]. 2020 Sep 1:2020.08.31.274639. doi: 10.1101/2020.08.31.274639. bioRxiv. 2020. PMID: 32908976 Free PMC article. Updated. Preprint.
Discovery of New States of Immunomodulation for Vaccine Adjuvants via High Throughput Screening: Expanding Innate Responses to PRRs.
Kim JY, Rosenberger MG, Chen S, Ip CK, Bahmani A, Chen Q, Shen J, Tang Y, Wang A, Kenna E, Son M, Tay S, Ferguson AL, Esser-Kahn AP. Kim JY, et al. Among authors: chen q, chen s. ACS Cent Sci. 2023 Feb 23;9(3):427-439. doi: 10.1021/acscentsci.2c01351. eCollection 2023 Mar 22. ACS Cent Sci. 2023. PMID: 36968540 Free PMC article.
Lattice Oxygen Activation through Deep Oxidation of Co4N by Jahn-Teller-active Dopants for Improved Electrocatalytic Oxygen Evolution.
Han J, Wang H, Wang Y, Zhang H, Li J, Xia Y, Zhou J, Wang Z, Luo M, Wang Y, Wang N, Cortés E, Wang Z, Vomiero A, Huang ZF, Ren H, Yuan X, Chen S, Feng D, Sun X, Liu Y, Liang H. Han J, et al. Among authors: chen s. Angew Chem Int Ed Engl. 2024 May 27:e202405839. doi: 10.1002/anie.202405839. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 38801294
Immune checkpoint inhibitors: breakthroughs in cancer treatment.
Kong X, Zhang J, Chen S, Wang X, Xi Q, Shen H, Zhang R. Kong X, et al. Among authors: chen s. Cancer Biol Med. 2024 May 24:j.issn.2095-3941.2024.0055. doi: 10.20892/j.issn.2095-3941.2024.0055. Online ahead of print. Cancer Biol Med. 2024. PMID: 38801082 Review.
Transcription factor EHF interacting with coactivator AJUBA aggravates malignancy and acts as a therapeutic target for gastroesophageal adenocarcinoma.
Peng L, Jiang Y, Chen H, Wang Y, Lan Q, Chen S, Huang Z, Zhang J, Tian D, Qiu Y, Cai D, Peng J, Lu D, Yuan X, Yang X, Yin D. Peng L, et al. Among authors: chen s. Acta Pharm Sin B. 2024 May;14(5):2119-2136. doi: 10.1016/j.apsb.2024.02.025. Epub 2024 Mar 4. Acta Pharm Sin B. 2024. PMID: 38799645 Free PMC article.
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