Alexopoulos LG - Search Results

1

Prediction of combination therapies based on topological modeling of the immune signaling network in multiple sclerosis.

Bernardo-Faura M, Rinas M, Wirbel J, Pertsovskaya I, Pliaka V, Messinis DE, Vila G, Sakellaropoulos T, Faigle W, Stridh P, Behrens JR, Olsson T, Martin R, Paul F, Alexopoulos LG, Villoslada P, Saez-Rodriguez J. Bernardo-Faura M, et al. Among authors: alexopoulos lg. Genome Med. 2021 Jul 16;13(1):117. doi: 10.1186/s13073-021-00925-8. Genome Med. 2021. PMID: 34271980 Free PMC article.

2

The logic of EGFR/ErbB signaling: theoretical properties and analysis of high-throughput data.

Samaga R, Saez-Rodriguez J, Alexopoulos LG, Sorger PK, Klamt S. Samaga R, et al. Among authors: alexopoulos lg. PLoS Comput Biol. 2009 Aug;5(8):e1000438. doi: 10.1371/journal.pcbi.1000438. Epub 2009 Aug 7. PLoS Comput Biol. 2009. PMID: 19662154 Free PMC article.

3

Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.

Saez-Rodriguez J, Alexopoulos LG, Epperlein J, Samaga R, Lauffenburger DA, Klamt S, Sorger PK. Saez-Rodriguez J, et al. Among authors: alexopoulos lg. Mol Syst Biol. 2009;5:331. doi: 10.1038/msb.2009.87. Epub 2009 Dec 1. Mol Syst Biol. 2009. PMID: 19953085 Free PMC article.

4

A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes.

Cosgrove BD, Alexopoulos LG, Saez-Rodriguez J, Griffith LG, Lauffenburger DA. Cosgrove BD, et al. Among authors: alexopoulos lg. Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:5452-5. doi: 10.1109/IEMBS.2009.5334019. Annu Int Conf IEEE Eng Med Biol Soc. 2009. PMID: 19964679 Free PMC article.

5

Identifying drug effects via pathway alterations using an integer linear programming optimization formulation on phosphoproteomic data.

Mitsos A, Melas IN, Siminelakis P, Chairakaki AD, Saez-Rodriguez J, Alexopoulos LG. Mitsos A, et al. Among authors: alexopoulos lg. PLoS Comput Biol. 2009 Dec;5(12):e1000591. doi: 10.1371/journal.pcbi.1000591. Epub 2009 Dec 4. PLoS Comput Biol. 2009. PMID: 19997482 Free PMC article.

6

Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes.

Alexopoulos LG, Saez-Rodriguez J, Cosgrove BD, Lauffenburger DA, Sorger PK. Alexopoulos LG, et al. Mol Cell Proteomics. 2010 Sep;9(9):1849-65. doi: 10.1074/mcp.M110.000406. Epub 2010 May 10. Mol Cell Proteomics. 2010. PMID: 20460255 Free PMC article.

7

Construction of signaling pathways and identification of drug effects on the liver cancer cell HepG2.

Alexopoulos LG, Melas IN, Chairakaki AD, Saez-Rodriguez J, Mitsos A. Alexopoulos LG, et al. Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:6717-20. doi: 10.1109/IEMBS.2010.5626246. Annu Int Conf IEEE Eng Med Biol Soc. 2010. PMID: 21096084

8

Setting the standards for signal transduction research.

Saez-Rodriguez J, Alexopoulos LG, Stolovitzky G. Saez-Rodriguez J, et al. Among authors: alexopoulos lg. Sci Signal. 2011 Feb 15;4(160):pe10. doi: 10.1126/scisignal.2001844. Sci Signal. 2011. PMID: 21325202

9

Combined logical and data-driven models for linking signalling pathways to cellular response.

Melas IN, Mitsos A, Messinis DE, Weiss TS, Alexopoulos LG. Melas IN, et al. Among authors: alexopoulos lg. BMC Syst Biol. 2011 Jul 5;5:107. doi: 10.1186/1752-0509-5-107. BMC Syst Biol. 2011. PMID: 21729292 Free PMC article.

10

Comparing signaling networks between normal and transformed hepatocytes using discrete logical models.

Saez-Rodriguez J, Alexopoulos LG, Zhang M, Morris MK, Lauffenburger DA, Sorger PK. Saez-Rodriguez J, et al. Among authors: alexopoulos lg. Cancer Res. 2011 Aug 15;71(16):5400-11. doi: 10.1158/0008-5472.CAN-10-4453. Epub 2011 Jul 8. Cancer Res. 2011. PMID: 21742771 Free PMC article.

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