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Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load.
Calsolaro V, Matthews PM, Donat CK, Livingston NR, Femminella GD, Guedes SS, Myers J, Fan Z, Tyacke RJ, Venkataraman AV, Perneczky R, Gunn R, Rabiner EA, Gentleman S, Parker CA, Murphy PS, Wren PB, Hinz R, Sastre M, Nutt DJ, Edison P. Calsolaro V, et al. Among authors: wren pb. Mol Psychiatry. 2021 Oct;26(10):5848-5855. doi: 10.1038/s41380-021-01193-z. Epub 2021 Jul 15. Mol Psychiatry. 2021. PMID: 34267329 Free PMC article.
Relationship between astrocyte reactivity, using novel 11C-BU99008 PET, and glucose metabolism, grey matter volume and amyloid load in cognitively impaired individuals.
Livingston NR, Calsolaro V, Hinz R, Nowell J, Raza S, Gentleman S, Tyacke RJ, Myers J, Venkataraman AV, Perneczky R, Gunn RN, Rabiner EA, Parker CA, Murphy PS, Wren PB, Nutt DJ, Matthews PM, Edison P. Livingston NR, et al. Among authors: wren pb. Mol Psychiatry. 2022 Apr;27(4):2019-2029. doi: 10.1038/s41380-021-01429-y. Epub 2022 Feb 7. Mol Psychiatry. 2022. PMID: 35125495 Free PMC article.
The unexpected surface of asteroid (101955) Bennu.
Lauretta DS, DellaGiustina DN, Bennett CA, Golish DR, Becker KJ, Balram-Knutson SS, Barnouin OS, Becker TL, Bottke WF, Boynton WV, Campins H, Clark BE, Connolly HC Jr, Drouet d'Aubigny CY, Dworkin JP, Emery JP, Enos HL, Hamilton VE, Hergenrother CW, Howell ES, Izawa MRM, Kaplan HH, Nolan MC, Rizk B, Roper HL, Scheeres DJ, Smith PH, Walsh KJ, Wolner CWV; OSIRIS-REx Team. Lauretta DS, et al. Nature. 2019 Apr;568(7750):55-60. doi: 10.1038/s41586-019-1033-6. Epub 2019 Mar 19. Nature. 2019. PMID: 30890786 Free PMC article.
GSK356278, a potent, selective, brain-penetrant phosphodiesterase 4 inhibitor that demonstrates anxiolytic and cognition-enhancing effects without inducing side effects in preclinical species.
Rutter AR, Poffe A, Cavallini P, Davis TG, Schneck J, Negri M, Vicentini E, Montanari D, Arban R, Gray FA, Davies CH, Wren PB. Rutter AR, et al. Among authors: wren pb. J Pharmacol Exp Ther. 2014 Jul;350(1):153-63. doi: 10.1124/jpet.114.214155. Epub 2014 Apr 30. J Pharmacol Exp Ther. 2014. PMID: 24784567