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Astrocytic interleukin-3 programs microglia and limits Alzheimer's disease.
McAlpine CS, Park J, Griciuc A, Kim E, Choi SH, Iwamoto Y, Kiss MG, Christie KA, Vinegoni C, Poller WC, Mindur JE, Chan CT, He S, Janssen H, Wong LP, Downey J, Singh S, Anzai A, Kahles F, Jorfi M, Feruglio PF, Sadreyev RI, Weissleder R, Kleinstiver BP, Nahrendorf M, Tanzi RE, Swirski FK. McAlpine CS, et al. Among authors: kleinstiver bp. Nature. 2021 Jul;595(7869):701-706. doi: 10.1038/s41586-021-03734-6. Epub 2021 Jul 14. Nature. 2021. PMID: 34262178 Free PMC article.
Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss.
György B, Nist-Lund C, Pan B, Asai Y, Karavitaki KD, Kleinstiver BP, Garcia SP, Zaborowski MP, Solanes P, Spataro S, Schneider BL, Joung JK, Géléoc GSG, Holt JR, Corey DP. György B, et al. Among authors: kleinstiver bp. Nat Med. 2019 Jul;25(7):1123-1130. doi: 10.1038/s41591-019-0500-9. Epub 2019 Jul 3. Nat Med. 2019. PMID: 31270503 Free PMC article.
Broad-spectrum anti-CRISPR proteins facilitate horizontal gene transfer.
Mahendra C, Christie KA, Osuna BA, Pinilla-Redondo R, Kleinstiver BP, Bondy-Denomy J. Mahendra C, et al. Among authors: kleinstiver bp. Nat Microbiol. 2020 Apr;5(4):620-629. doi: 10.1038/s41564-020-0692-2. Epub 2020 Mar 26. Nat Microbiol. 2020. PMID: 32218510 Free PMC article.
Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes.
Osuna BA, Karambelkar S, Mahendra C, Christie KA, Garcia B, Davidson AR, Kleinstiver BP, Kilcher S, Bondy-Denomy J. Osuna BA, et al. Among authors: kleinstiver bp. Cell Host Microbe. 2020 Jul 8;28(1):31-40.e9. doi: 10.1016/j.chom.2020.04.001. Epub 2020 Apr 22. Cell Host Microbe. 2020. PMID: 32325050 Free PMC article.
Making the cut with PAMless CRISPR-Cas enzymes.
Christie KA, Kleinstiver BP. Christie KA, et al. Among authors: kleinstiver bp. Trends Genet. 2021 Dec;37(12):1053-1055. doi: 10.1016/j.tig.2021.09.002. Epub 2021 Sep 22. Trends Genet. 2021. PMID: 34563399 Free PMC article.
Precise DNA cleavage using CRISPR-SpRYgests.
Christie KA, Guo JA, Silverstein RA, Doll RM, Mabuchi M, Stutzman HE, Lin J, Ma L, Walton RT, Pinello L, Robb GB, Kleinstiver BP. Christie KA, et al. Among authors: kleinstiver bp. Nat Biotechnol. 2023 Mar;41(3):409-416. doi: 10.1038/s41587-022-01492-y. Epub 2022 Oct 6. Nat Biotechnol. 2023. PMID: 36203014 Free PMC article.
Base editing as a genetic treatment for spinal muscular atrophy.
Alves CRR, Ha LL, Yaworski R, Lazzarotto CR, Christie KA, Reilly A, Beauvais A, Doll RM, de la Cruz D, Maguire CA, Swoboda KJ, Tsai SQ, Kothary R, Kleinstiver BP. Alves CRR, et al. Among authors: kleinstiver bp. bioRxiv [Preprint]. 2023 Jan 21:2023.01.20.524978. doi: 10.1101/2023.01.20.524978. bioRxiv. 2023. PMID: 36711797 Free PMC article. Preprint.
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy.
Alves CRR, Ha LL, Yaworski R, Sutton ER, Lazzarotto CR, Christie KA, Reilly A, Beauvais A, Doll RM, de la Cruz D, Maguire CA, Swoboda KJ, Tsai SQ, Kothary R, Kleinstiver BP. Alves CRR, et al. Among authors: kleinstiver bp. Nat Biomed Eng. 2024 Feb;8(2):118-131. doi: 10.1038/s41551-023-01132-z. Epub 2023 Dec 6. Nat Biomed Eng. 2024. PMID: 38057426 Free PMC article.
73 results