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A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration.
Elife. 2021 Jun 29;10:e66694. doi: 10.7554/eLife.66694.
Elife. 2021.
PMID: 34184985
Free PMC article.
Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1.
Loring HS, Icso JD, Nemmara VV, Thompson PR.
Loring HS, et al. Among authors: icso jd.
Biochemistry. 2020 Mar 3;59(8):933-942. doi: 10.1021/acs.biochem.9b01078. Epub 2020 Feb 17.
Biochemistry. 2020.
PMID: 32049506
Free PMC article.
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Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition.
Peterson ND, Icso JD, Salisbury JE, Rodríguez T, Thompson PR, Pukkila-Worley R.
Peterson ND, et al. Among authors: icso jd.
Elife. 2022 Jan 31;11:e74206. doi: 10.7554/eLife.74206.
Elife. 2022.
PMID: 35098926
Free PMC article.
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The chemical biology of NAD+ regulation in axon degeneration.
Icso JD, Thompson PR.
Icso JD, et al.
Curr Opin Chem Biol. 2022 Aug;69:102176. doi: 10.1016/j.cbpa.2022.102176. Epub 2022 Jul 1.
Curr Opin Chem Biol. 2022.
PMID: 35780654
Free PMC article.
Review.
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SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism.
Icso JD, Barasa L, Thompson PR.
Icso JD, et al.
Biochemistry. 2023 Jul 4;62(13):2065-2078. doi: 10.1021/acs.biochem.3c00081. Epub 2023 Jun 12.
Biochemistry. 2023.
PMID: 37307562
Free PMC article.
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A phase transition reduces the threshold for nicotinamide mononucleotide-based activation of SARM1, an NAD(P) hydrolase, to physiologically relevant levels.
Icso JD, Thompson PR.
Icso JD, et al.
J Biol Chem. 2023 Nov;299(11):105284. doi: 10.1016/j.jbc.2023.105284. Epub 2023 Sep 22.
J Biol Chem. 2023.
PMID: 37742918
Free PMC article.
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