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Page 1
Essential role for Gata2 in modulating lineage output from hematopoietic stem cells in zebrafish.
Gioacchino E, Koyunlar C, Zink J, de Looper H, de Jong M, Dobrzycki T, Mahony CB, Hoogenboezem R, Bosch D, van Strien PMH, van Royen ME, French PJ, Bindels E, Gussinklo KJ, Monteiro R, Touw IP, de Pater E. Gioacchino E, et al. Among authors: bindels e. Blood Adv. 2021 Jul 13;5(13):2687-2700. doi: 10.1182/bloodadvances.2020002993. Blood Adv. 2021. PMID: 34170285 Free PMC article.
Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1.
Lugthart S, Figueroa ME, Bindels E, Skrabanek L, Valk PJ, Li Y, Meyer S, Erpelinck-Verschueren C, Greally J, Löwenberg B, Melnick A, Delwel R. Lugthart S, et al. Among authors: bindels e. Blood. 2011 Jan 6;117(1):234-41. doi: 10.1182/blood-2010-04-281337. Epub 2010 Sep 20. Blood. 2011. PMID: 20855866 Free PMC article.
EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs.
Bindels EM, Havermans M, Lugthart S, Erpelinck C, Wocjtowicz E, Krivtsov AV, Rombouts E, Armstrong SA, Taskesen E, Haanstra JR, Beverloo HB, Döhner H, Hudson WA, Kersey JH, Delwel R, Kumar AR. Bindels EM, et al. Blood. 2012 Jun 14;119(24):5838-49. doi: 10.1182/blood-2011-11-393827. Epub 2012 May 2. Blood. 2012. PMID: 22553314 Free PMC article.
Two splice-factor mutant leukemia subgroups uncovered at the boundaries of MDS and AML using combined gene expression and DNA-methylation profiling.
Taskesen E, Havermans M, van Lom K, Sanders MA, van Norden Y, Bindels E, Hoogenboezem R, Reinders MJ, Figueroa ME, Valk PJ, Löwenberg B, Melnick A, Delwel R. Taskesen E, et al. Among authors: bindels e. Blood. 2014 May 22;123(21):3327-35. doi: 10.1182/blood-2013-07-512855. Epub 2014 Mar 25. Blood. 2014. PMID: 24668493 Free article.
A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia.
Gröschel S, Sanders MA, Hoogenboezem R, de Wit E, Bouwman BAM, Erpelinck C, van der Velden VHJ, Havermans M, Avellino R, van Lom K, Rombouts EJ, van Duin M, Döhner K, Beverloo HB, Bradner JE, Döhner H, Löwenberg B, Valk PJM, Bindels EMJ, de Laat W, Delwel R. Gröschel S, et al. Among authors: bindels emj. Cell. 2014 Apr 10;157(2):369-381. doi: 10.1016/j.cell.2014.02.019. Epub 2014 Apr 3. Cell. 2014. PMID: 24703711 Free article.
Deficiency of the ribosome biogenesis gene Sbds in hematopoietic stem and progenitor cells causes neutropenia in mice by attenuating lineage progression in myelocytes.
Zambetti NA, Bindels EM, Van Strien PM, Valkhof MG, Adisty MN, Hoogenboezem RM, Sanders MA, Rommens JM, Touw IP, Raaijmakers MH. Zambetti NA, et al. Haematologica. 2015 Oct;100(10):1285-93. doi: 10.3324/haematol.2015.131573. Epub 2015 Jul 16. Haematologica. 2015. PMID: 26185170 Free PMC article.
An autonomous CEBPA enhancer specific for myeloid-lineage priming and neutrophilic differentiation.
Avellino R, Havermans M, Erpelinck C, Sanders MA, Hoogenboezem R, van de Werken HJ, Rombouts E, van Lom K, van Strien PM, Gebhard C, Rehli M, Pimanda J, Beck D, Erkeland S, Kuiken T, de Looper H, Gröschel S, Touw I, Bindels E, Delwel R. Avellino R, et al. Among authors: bindels e. Blood. 2016 Jun 16;127(24):2991-3003. doi: 10.1182/blood-2016-01-695759. Epub 2016 Mar 10. Blood. 2016. PMID: 26966090 Free PMC article.
Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs.
Chen S, Zambetti NA, Bindels EM, Kenswill K, Mylona AM, Adisty NM, Hoogenboezem RM, Sanders MA, Cremers EM, Westers TM, Jansen JH, van de Loosdrecht AA, Raaijmakers MH. Chen S, et al. Among authors: bindels em. Leukemia. 2016 Sep;30(9):1938-42. doi: 10.1038/leu.2016.91. Epub 2016 Apr 25. Leukemia. 2016. PMID: 27109510 Free PMC article. No abstract available.
Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia.
Zambetti NA, Ping Z, Chen S, Kenswil KJG, Mylona MA, Sanders MA, Hoogenboezem RM, Bindels EMJ, Adisty MN, Van Strien PMH, van der Leije CS, Westers TM, Cremers EMP, Milanese C, Mastroberardino PG, van Leeuwen JPTM, van der Eerden BCJ, Touw IP, Kuijpers TW, Kanaar R, van de Loosdrecht AA, Vogl T, Raaijmakers MHGP. Zambetti NA, et al. Cell Stem Cell. 2016 Nov 3;19(5):613-627. doi: 10.1016/j.stem.2016.08.021. Epub 2016 Sep 22. Cell Stem Cell. 2016. PMID: 27666011 Free article.
83 results