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The kinesin of the flagellum attachment zone in Leishmania is required for cell morphogenesis, cell division and virulence in the mammalian host.
Corrales RM, Vaselek S, Neish R, Berry L, Brunet CD, Crobu L, Kuk N, Mateos-Langerak J, Robinson DR, Volf P, Mottram JC, Sterkers Y, Bastien P. Corrales RM, et al. Among authors: mottram jc. PLoS Pathog. 2021 Jun 18;17(6):e1009666. doi: 10.1371/journal.ppat.1009666. eCollection 2021 Jun. PLoS Pathog. 2021. PMID: 34143858 Free PMC article.
Ecotin-like serine peptidase inhibitor ISP1 of Leishmania major plays a role in flagellar pocket dynamics and promastigote differentiation.
Morrison LS, Goundry A, Faria MS, Tetley L, Eschenlauer SC, Westrop GD, Dostalova A, Volf P, Coombs GH, Lima AP, Mottram JC. Morrison LS, et al. Among authors: mottram jc. Cell Microbiol. 2012 Aug;14(8):1271-86. doi: 10.1111/j.1462-5822.2012.01798.x. Epub 2012 May 8. Cell Microbiol. 2012. PMID: 22486816 Free PMC article.
Leishmania flagellum attachment zone is critical for flagellar pocket shape, development in the sand fly, and pathogenicity in the host.
Sunter JD, Yanase R, Wang Z, Catta-Preta CMC, Moreira-Leite F, Myskova J, Pruzinova K, Volf P, Mottram JC, Gull K. Sunter JD, et al. Among authors: mottram jc. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6351-6360. doi: 10.1073/pnas.1812462116. Epub 2019 Mar 8. Proc Natl Acad Sci U S A. 2019. PMID: 30850532 Free PMC article.
Essential roles for deubiquitination in Leishmania life cycle progression.
Damianou A, Burge RJ, Catta-Preta CMC, Geoghegan V, Nievas YR, Newling K, Brown E, Burchmore R, Rodenko B, Mottram JC. Damianou A, et al. Among authors: mottram jc. PLoS Pathog. 2020 Jun 16;16(6):e1008455. doi: 10.1371/journal.ppat.1008455. eCollection 2020 Jun. PLoS Pathog. 2020. PMID: 32544189 Free PMC article.
Role for the flagellum attachment zone in Leishmania anterior cell tip morphogenesis.
Halliday C, Yanase R, Catta-Preta CMC, Moreira-Leite F, Myskova J, Pruzinova K, Volf P, Mottram JC, Sunter JD. Halliday C, et al. Among authors: mottram jc. PLoS Pathog. 2020 Oct 22;16(10):e1008494. doi: 10.1371/journal.ppat.1008494. eCollection 2020 Oct. PLoS Pathog. 2020. PMID: 33091070 Free PMC article.
Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival.
Baker N, Catta-Preta CMC, Neish R, Sadlova J, Powell B, Alves-Ferreira EVC, Geoghegan V, Carnielli JBT, Newling K, Hughes C, Vojtkova B, Anand J, Mihut A, Walrad PB, Wilson LG, Pitchford JW, Volf P, Mottram JC. Baker N, et al. Among authors: mottram jc. Nat Commun. 2021 Feb 23;12(1):1244. doi: 10.1038/s41467-021-21360-8. Nat Commun. 2021. PMID: 33623024 Free PMC article.
260 results