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Distances from ligands as main predictive features for pathogenicity and functional effect of variants in NMDA receptors.
Montanucci L, Brünger T, Bhattarai N, Boßelmann CM, Kim S, Allen JP, Zhang J, Klöckner C, Fariselli P, May P, Lemke JR, Myers SJ, Yuan H, Traynelis SF, Lal D. Montanucci L, et al. Among authors: lemke jr. medRxiv [Preprint]. 2024 May 7:2024.05.06.24306939. doi: 10.1101/2024.05.06.24306939. medRxiv. 2024. PMID: 38766179 Free PMC article. Preprint.
Expanding the Chemical Space of Transforming Growth Factor-β (TGFβ) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives.
Längle D, Wojtowicz-Piotrowski S, Priegann T, Keller N, Wesseler F, Reckzeh ES, Steffens K, Grathwol C, Lemke J, Flasshoff M, Näther C, Jonson AC, Link A, Koch O, Di Guglielmo GM, Schade D. Längle D, et al. Among authors: lemke j. ACS Pharmacol Transl Sci. 2024 Mar 21;7(4):1069-1085. doi: 10.1021/acsptsci.3c00371. eCollection 2024 Apr 12. ACS Pharmacol Transl Sci. 2024. PMID: 38633593
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.
Xu Y, Song R, Perszyk RE, Chen W, Kim S, Park KL, Allen JP, Nocilla KA, Zhang J, XiangWei W, Tankovic A, McDaniels ED, Sheikh R, Mizu RK, Karamchandani MM, Hu C, Kusumoto H, Pecha J, Cappuccio G, Gaitanis J, Sullivan J, Shashi V, Petrovski S, Jauss RT, Lee HK, Bozarth X, Lynch DR, Helbig I, Pierson TM, Boerkoel CF, Myers SJ, Lemke JR, Benke TA, Yuan H, Traynelis SF. Xu Y, et al. Among authors: lemke jr. Cell Mol Life Sci. 2024 Mar 28;81(1):153. doi: 10.1007/s00018-023-05069-z. Cell Mol Life Sci. 2024. PMID: 38538865 Free PMC article.
Cases of trisomy 21 and trisomy 18 among historic and prehistoric individuals discovered from ancient DNA.
Rohrlach AB, Rivollat M, de-Miguel-Ibáñez P, Moilanen U, Liira AM, Teixeira JC, Roca-Rada X, Armendáriz-Martija J, Boyadzhiev K, Boyadzhiev Y, Llamas B, Tiliakou A, Mötsch A, Tuke J, Prevedorou EA, Polychronakou-Sgouritsa N, Buikstra J, Onkamo P, Stockhammer PW, Heyne HO, Lemke JR, Risch R, Schiffels S, Krause J, Haak W, Prüfer K. Rohrlach AB, et al. Among authors: lemke jr. Nat Commun. 2024 Feb 20;15(1):1294. doi: 10.1038/s41467-024-45438-1. Nat Commun. 2024. PMID: 38378781 Free PMC article.
366 results