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Targeting glutamine dependence through GLS1 inhibition suppresses ARID1A-inactivated clear cell ovarian carcinoma.
Wu S, Fukumoto T, Lin J, Nacarelli T, Wang Y, Ong D, Liu H, Fatkhutdinov N, Zundell JA, Karakashev S, Zhou W, Schwartz LE, Tang HY, Drapkin R, Liu Q, Huntsman DG, Kossenkov AV, Speicher DW, Schug ZT, Van Dang C, Zhang R. Wu S, et al. Among authors: ong d. Nat Cancer. 2021 Feb;2(2):189-200. doi: 10.1038/s43018-020-00160-x. Epub 2021 Jan 11. Nat Cancer. 2021. PMID: 34085048 Free PMC article.
Alanine supplementation exploits glutamine dependency induced by SMARCA4/2-loss.
Zhu X, Fu Z, Chen SY, Ong D, Aceto G, Ho R, Steinberger J, Monast A, Pilon V, Li E, Ta M, Ching K, Adams BN, Negri GL, Choiniere L, Fu L, Pavlakis K, Pirrotte P, Avizonis DZ, Trent J, Weissman BE, Klein Geltink RI, Morin GB, Park M, Huntsman DG, Foulkes WD, Wang Y, Huang S. Zhu X, et al. Among authors: ong d. Nat Commun. 2023 May 20;14(1):2894. doi: 10.1038/s41467-023-38594-3. Nat Commun. 2023. PMID: 37210563 Free PMC article.
PHF2 regulates genome topology and DNA replication in neural stem cells via cohesin.
Feng J, Chuah YH, Liang Y, Cipta NO, Zeng Y, Warrier T, Elfar GARE, Yoon J, Grinchuk OV, Tay EXY, Lok KZ, Zheng ZQ, Khong ZJ, Chong ZS, Teo J, Sanford EM, Neo CJY, Chiu HY, Leung JY, Wang LC, Lim YT, Zhao T, Sobota RM, Crasta KC, Tergaonkar V, Taneja R, Ng SY, Cheok CF, Ling SC, Loh YH, Ong DST. Feng J, et al. Among authors: ong dst. Nucleic Acids Res. 2024 May 29:gkae457. doi: 10.1093/nar/gkae457. Online ahead of print. Nucleic Acids Res. 2024. PMID: 38808662
A multimodal atlas of hepatocellular carcinoma reveals convergent evolutionary paths and 'bad apple' effect on clinical trajectory.
Chen J, Kaya NA, Zhang Y, Kendarsari RI, Sekar K, Lee Chong S, Seshachalam VP, Ling WH, Jin Phua CZ, Lai H, Yang H, Lu B, Lim JQ, Ma S, Chew SC, Chua KP, Alvarez JJS, Wu L, Ooi L, Chung AY, Cheow PC, Kam JH, Kow AW, Ganpathi IS, Bunchaliew C, Thammasiri J, Koh PS, Ong DB, Lim J, de Villa VH, Dela Cruz RD, Loh TJ, Wan WK, Leow WQ, Yang Y, Liu J, Skanderup AJ, Pang YH, Soon GST, Madhavan K, Lim TK, Bonney G, Goh BKP, Chew V, Dan YY, Toh HC, Foo RS, Tam WL, Zhai W, Chow PK. Chen J, et al. Among authors: ong db. J Hepatol. 2024 May 21:S0168-8278(24)00352-0. doi: 10.1016/j.jhep.2024.05.017. Online ahead of print. J Hepatol. 2024. PMID: 38782118 Free article.
Characteristics and outcomes of COVID-19 patients admitted to hospital with and without respiratory symptoms.
Citarella BW, Kartsonaki C, Ibáñez-Prada ED, Gonçalves BP, Baruch J, Escher M, Pritchard MG, Wei J, Philippy F, Dagens A, Hall M, Lee J, Kutsogiannis DJ, Wils EJ, Fernandes MA, Tirupakuzhi Vijayaraghavan BK, Panda PK, Martin-Loeches I, Ohshimo S, Fatoni AZ, Horby P, Dunning J, Rello J, Merson L, Rojek A, Vaillant M, Olliaro P, Reyes LF; ISARIC Clinical Characterisation Group. Citarella BW, et al. Heliyon. 2024 May 4;10(10):e29591. doi: 10.1016/j.heliyon.2024.e29591. eCollection 2024 May 30. Heliyon. 2024. PMID: 38779000 Free PMC article.
METTL8 links mt-tRNA m3C modification to the HIF1α/RTK/Akt axis to sustain GBM stemness and tumorigenicity.
Lee BWL, Chuah YH, Yoon J, Grinchuk OV, Liang Y, Hirpara JL, Shen Y, Wang LC, Lim YT, Zhao T, Sobota RM, Yeo TT, Wong ALA, Teo K, Nga VDW, Tan BWQ, Suda T, Toh TB, Pervaiz S, Lin Z, Ong DST. Lee BWL, et al. Among authors: ong dst. Cell Death Dis. 2024 May 14;15(5):338. doi: 10.1038/s41419-024-06718-2. Cell Death Dis. 2024. PMID: 38744809 Free PMC article.
590 results