Gascoigne NRJ - Search Results

1

Canonical T cell receptor docking on peptide-MHC is essential for T cell signaling.

Zareie P, Szeto C, Farenc C, Gunasinghe SD, Kolawole EM, Nguyen A, Blyth C, Sng XYX, Li J, Jones CM, Fulcher AJ, Jacobs JR, Wei Q, Wojciech L, Petersen J, Gascoigne NRJ, Evavold BD, Gaus K, Gras S, Rossjohn J, La Gruta NL. Zareie P, et al. Among authors: gascoigne nrj. Science. 2021 Jun 4;372(6546):eabe9124. doi: 10.1126/science.abe9124. Science. 2021. PMID: 34083463

2

Interaction of the T cell receptor with bacterial superantigens.

Gascoigne NR. Gascoigne NR. Semin Immunol. 1993 Feb;5(1):13-21. doi: 10.1006/smim.1993.1003. Semin Immunol. 1993. PMID: 8467090 Review.

3

Control of MHC restriction by TCR Valpha CDR1 and CDR2.

Sim BC, Zerva L, Greene MI, Gascoigne NR. Sim BC, et al. Science. 1996 Aug 16;273(5277):963-6. doi: 10.1126/science.273.5277.963. Science. 1996. PMID: 8688082

4

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide-MHC.

Hoerter JA, Brzostek J, Artyomov MN, Abel SM, Casas J, Rybakin V, Ampudia J, Lotz C, Connolly JM, Chakraborty AK, Gould KG, Gascoigne NR. Hoerter JA, et al. J Exp Med. 2013 Aug 26;210(9):1807-21. doi: 10.1084/jem.20122528. Epub 2013 Aug 12. J Exp Med. 2013. PMID: 23940257 Free PMC article.

5

Ligand-engaged TCR is triggered by Lck not associated with CD8 coreceptor.

Casas J, Brzostek J, Zarnitsyna VI, Hong JS, Wei Q, Hoerter JA, Fu G, Ampudia J, Zamoyska R, Zhu C, Gascoigne NR. Casas J, et al. Nat Commun. 2014 Nov 27;5:5624. doi: 10.1038/ncomms6624. Nat Commun. 2014. PMID: 25427562 Free PMC article.

6

Thymic Origins of T Cell Receptor Alloreactivity.

Brzostek J, Gascoigne NRJ. Brzostek J, et al. Among authors: gascoigne nrj. Transplantation. 2017 Jul;101(7):1535-1541. doi: 10.1097/TP.0000000000001654. Transplantation. 2017. PMID: 28114168 Review.

7

Development of a screening strategy for new modulators of T cell receptor signaling and T cell activation.

Chen EW, Brzostek J, Gascoigne NRJ, Rybakin V. Chen EW, et al. Among authors: gascoigne nrj. Sci Rep. 2018 Jul 3;8(1):10046. doi: 10.1038/s41598-018-28106-5. Sci Rep. 2018. PMID: 29968737 Free PMC article.

8

Nonstimulatory peptide-MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling.

Zhao X, Sankaran S, Yap J, Too CT, Ho ZZ, Dolton G, Legut M, Ren EC, Sewell AK, Bertoletti A, MacAry PA, Brzostek J, Gascoigne NRJ. Zhao X, et al. Among authors: gascoigne nrj. Nat Commun. 2018 Jul 13;9(1):2716. doi: 10.1038/s41467-018-05288-0. Nat Commun. 2018. PMID: 30006605 Free PMC article.

9

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation.

Zhao X, Hamidinia M, Choo JAL, Too CT, Ho ZZ, Ren EC, Bertoletti A, MacAry PA, Gould KG, Brzostek J, Gascoigne NRJ. Zhao X, et al. Among authors: gascoigne nrj. J Vis Exp. 2019 Feb 28;(144). doi: 10.3791/59126. J Vis Exp. 2019. PMID: 30882785 Free article.

10

T cell receptor and cytokine signal integration in CD8⁺ T cells is mediated by the protein Themis.

Brzostek J, Gautam N, Zhao X, Chen EW, Mehta M, Tung DWH, Chua YL, Yap J, Cho SH, Sankaran S, Rybakin V, Fu G, Gascoigne NRJ. Brzostek J, et al. Among authors: gascoigne nrj. Nat Immunol. 2020 Feb;21(2):186-198. doi: 10.1038/s41590-019-0570-3. Epub 2020 Jan 13. Nat Immunol. 2020. PMID: 31932808

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