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Pre-Operative Decitabine in Colon Cancer Patients: Analyses on WNT Target Methylation and Expression.
Linnekamp JF, Kandimalla R, Fessler E, de Jong JH, Rodermond HM, van Bochove GGW, The FO, Punt CJA, Bemelman WA, van de Ven AWH, Tanis PJ, Kemper EM, Koens L, Dekker E, Vermeulen L, van Laarhoven HWM, Medema JP. Linnekamp JF, et al. Cancers (Basel). 2021 May 13;13(10):2357. doi: 10.3390/cancers13102357. Cancers (Basel). 2021. PMID: 34068407 Free PMC article.
A multidimensional network approach reveals microRNAs as determinants of the mesenchymal colorectal cancer subtype.
Fessler E, Jansen M, De Sousa E Melo F, Zhao L, Prasetyanti PR, Rodermond H, Kandimalla R, Linnekamp JF, Franitza M, van Hooff SR, de Jong JH, Oppeneer SC, van Noesel CJ, Dekker E, Stassi G, Wang X, Medema JP, Vermeulen L. Fessler E, et al. Among authors: linnekamp jf. Oncogene. 2016 Nov 17;35(46):6026-6037. doi: 10.1038/onc.2016.134. Epub 2016 May 9. Oncogene. 2016. PMID: 27157610 Free PMC article.
TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype.
Fessler E, Drost J, van Hooff SR, Linnekamp JF, Wang X, Jansen M, De Sousa E Melo F, Prasetyanti PR, IJspeert JE, Franitza M, Nürnberg P, van Noesel CJ, Dekker E, Vermeulen L, Clevers H, Medema JP. Fessler E, et al. Among authors: linnekamp jf. EMBO Mol Med. 2016 Jul 1;8(7):745-60. doi: 10.15252/emmm.201606184. Print 2016 Jul. EMBO Mol Med. 2016. PMID: 27221051 Free PMC article.
Loss of KCNQ1 expression in stage II and stage III colon cancer is a strong prognostic factor for disease recurrence.
den Uil SH, Coupé VM, Linnekamp JF, van den Broek E, Goos JA, Delis-van Diemen PM, Belt EJ, van Grieken NC, Scott PM, Vermeulen L, Medema JP, Bril H, Stockmann HB, Cormier RT, Meijer GA, Fijneman RJ. den Uil SH, et al. Among authors: linnekamp jf. Br J Cancer. 2016 Dec 6;115(12):1565-1574. doi: 10.1038/bjc.2016.376. Epub 2016 Nov 17. Br J Cancer. 2016. PMID: 27855440 Free PMC article.
Consensus molecular subtypes of colorectal cancer are recapitulated in in vitro and in vivo models.
Linnekamp JF, Hooff SRV, Prasetyanti PR, Kandimalla R, Buikhuisen JY, Fessler E, Ramesh P, Lee KAST, Bochove GGW, de Jong JH, Cameron K, Leersum RV, Rodermond HM, Franitza M, Nürnberg P, Mangiapane LR, Wang X, Clevers H, Vermeulen L, Stassi G, Medema JP. Linnekamp JF, et al. Cell Death Differ. 2018 Mar;25(3):616-633. doi: 10.1038/s41418-017-0011-5. Epub 2018 Jan 5. Cell Death Differ. 2018. PMID: 29305587 Free PMC article.
CFTR is a tumor suppressor gene in murine and human intestinal cancer.
Than BL, Linnekamp JF, Starr TK, Largaespada DA, Rod A, Zhang Y, Bruner V, Abrahante J, Schumann A, Luczak T, Walter J, Niemczyk A, O'Sullivan MG, Medema JP, Fijneman RJ, Meijer GA, Van den Broek E, Hodges CA, Scott PM, Vermeulen L, Cormier RT. Than BL, et al. Among authors: linnekamp jf. Oncogene. 2016 Aug 11;35(32):4179-87. doi: 10.1038/onc.2015.483. Epub 2016 Jan 11. Oncogene. 2016. PMID: 26751771 Free PMC article.
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