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Pharmacokinetics, pharmacodynamics, and tolerability of subcutaneous administration of a novel glycoprotein IIb/IIIa inhibitor, RUC-4, in patients with ST-segment elevation myocardial infarction.
Bor WL, Zheng KL, Tavenier AH, Gibson CM, Granger CB, Bentur O, Lobatto R, Postma S, Coller BS, van 't Hof AWJ, Ten Berg JM. Bor WL, et al. Among authors: coller bs. EuroIntervention. 2021 Aug 6;17(5):e401-e410. doi: 10.4244/EIJ-D-21-00287. EuroIntervention. 2021. PMID: 34031019 Free PMC article. Clinical Trial.
First Human Use of RUC-4: A Nonactivating Second-Generation Small-Molecule Platelet Glycoprotein IIb/IIIa (Integrin αIIbβ3) Inhibitor Designed for Subcutaneous Point-of-Care Treatment of ST-Segment-Elevation Myocardial Infarction.
Kereiakes DJ, Henry TD, DeMaria AN, Bentur O, Carlson M, Seng Yue C, Martin LH, Midkiff J, Mueller M, Meek T, Garza D, Gibson CM, Coller BS. Kereiakes DJ, et al. Among authors: coller bs. J Am Heart Assoc. 2020 Sep;9(17):e016552. doi: 10.1161/JAHA.120.016552. Epub 2020 Aug 26. J Am Heart Assoc. 2020. PMID: 32844723 Free PMC article. Clinical Trial.
Critical Analysis of Thrombocytopenia Associated With Glycoprotein IIb/IIIa Inhibitors and Potential Role of Zalunfiban, a Novel Small Molecule Glycoprotein Inhibitor, in Understanding the Mechanism(s).
Rikken SAOF, van 't Hof AWJ, Ten Berg JM, Kereiakes DJ, Coller BS. Rikken SAOF, et al. Among authors: coller bs. J Am Heart Assoc. 2023 Dec 19;12(24):e031855. doi: 10.1161/JAHA.123.031855. Epub 2023 Dec 8. J Am Heart Assoc. 2023. PMID: 38063187 Free PMC article. Review.
RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction.
Li J, Vootukuri S, Shang Y, Negri A, Jiang JK, Nedelman M, Diacovo TG, Filizola M, Thomas CJ, Coller BS. Li J, et al. Among authors: coller bs. Arterioscler Thromb Vasc Biol. 2014 Oct;34(10):2321-9. doi: 10.1161/ATVBAHA.114.303724. Epub 2014 Aug 21. Arterioscler Thromb Vasc Biol. 2014. PMID: 25147334 Free PMC article.
285 results