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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.
Immunity. 2021 Jun 8;54(6):1154-1167.e7. doi: 10.1016/j.immuni.2021.04.019. Epub 2021 May 11.
Immunity. 2021.
PMID: 33979578
Free PMC article.
TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8+ T cell and XCR1+ dendritic cell spatial co-localization.
Gardner A, de Mingo Pulido Á, Hänggi K, Bazargan S, Onimus A, Kasprzak A, Conejo-Garcia JR, Rejniak KA, Ruffell B.
Gardner A, et al. Among authors: onimus a.
J Immunother Cancer. 2022 Jan;10(1):e003571. doi: 10.1136/jitc-2021-003571.
J Immunother Cancer. 2022.
PMID: 34987021
Free PMC article.
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Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes.
Ward GA, Dalton RP 3rd, Meyer BS, McLemore AF, Aldrich AL, Lam NB, Onimus AH, Vincelette ND, Trinh TL, Chen X, Calescibetta AR, Christiansen SM, Hou HA, Johnson JO, Wright KL, Padron E, Eksioglu EA, List AF.
Ward GA, et al. Among authors: onimus ah.
Int J Mol Sci. 2023 Feb 15;24(4):3896. doi: 10.3390/ijms24043896.
Int J Mol Sci. 2023.
PMID: 36835307
Free PMC article.
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