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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.
de Mingo Pulido Á, Hänggi K, Celias DP, Gardner A, Li J, Batista-Bittencourt B, Mohamed E, Trillo-Tinoco J, Osunmakinde O, Peña R, Onimus A, Kaisho T, Kaufmann J, McEachern K, Soliman H, Luca VC, Rodriguez PC, Yu X, Ruffell B. de Mingo Pulido Á, et al. Among authors: kaufmann j. Immunity. 2021 Jun 8;54(6):1154-1167.e7. doi: 10.1016/j.immuni.2021.04.019. Epub 2021 May 11. Immunity. 2021. PMID: 33979578 Free PMC article.
Preclinical investigation of combined gene-mediated cytotoxic immunotherapy and immune checkpoint blockade in glioblastoma.
Speranza MC, Passaro C, Ricklefs F, Kasai K, Klein SR, Nakashima H, Kaufmann JK, Ahmed AK, Nowicki MO, Obi P, Bronisz A, Aguilar-Cordova E, Aguilar LK, Guzik BW, Breakefield X, Weissleder R, Freeman GJ, Reardon DA, Wen PY, Chiocca EA, Lawler SE. Speranza MC, et al. Among authors: kaufmann jk. Neuro Oncol. 2018 Jan 22;20(2):225-235. doi: 10.1093/neuonc/nox139. Neuro Oncol. 2018. PMID: 29016938 Free PMC article.
Glioma virus therapies between bench and bedside.
Kaufmann JK, Chiocca EA. Kaufmann JK, et al. Neuro Oncol. 2014 Mar;16(3):334-51. doi: 10.1093/neuonc/not310. Epub 2014 Jan 26. Neuro Oncol. 2014. PMID: 24470549 Free PMC article. Review.
Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma.
Nakashima H, Kaufmann JK, Wang PY, Nguyen T, Speranza MC, Kasai K, Okemoto K, Otsuki A, Nakano I, Fernandez S, Goins WF, Grandi P, Glorioso JC, Lawler S, Cripe TP, Chiocca EA. Nakashima H, et al. J Clin Invest. 2015 Nov 2;125(11):4269-80. doi: 10.1172/JCI80713. Epub 2015 Oct 20. J Clin Invest. 2015. PMID: 26524593 Free PMC article.
CTLA-4 and PD-L1 checkpoint blockade enhances oncolytic measles virus therapy.
Engeland CE, Grossardt C, Veinalde R, Bossow S, Lutz D, Kaufmann JK, Shevchenko I, Umansky V, Nettelbeck DM, Weichert W, Jäger D, von Kalle C, Ungerechts G. Engeland CE, et al. Mol Ther. 2014 Nov;22(11):1949-59. doi: 10.1038/mt.2014.160. Epub 2014 Aug 26. Mol Ther. 2014. PMID: 25156126 Free PMC article.
The HDAC Inhibitors Scriptaid and LBH589 Combined with the Oncolytic Virus Delta24-RGD Exert Enhanced Anti-Tumor Efficacy in Patient-Derived Glioblastoma Cells.
Berghauser Pont LM, Kleijn A, Kloezeman JJ, van den Bossche W, Kaufmann JK, de Vrij J, Leenstra S, Dirven CM, Lamfers ML. Berghauser Pont LM, et al. Among authors: kaufmann jk. PLoS One. 2015 May 18;10(5):e0127058. doi: 10.1371/journal.pone.0127058. eCollection 2015. PLoS One. 2015. PMID: 25993039 Free PMC article.
688 results