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The inhibitory receptor TIM-3 limits activation of the cGAS-STING pathway in intra-tumoral dendritic cells by suppressing extracellular DNA uptake.
de Mingo Pulido Á, Hänggi K, Celias DP, Gardner A, Li J, Batista-Bittencourt B, Mohamed E, Trillo-Tinoco J, Osunmakinde O, Peña R, Onimus A, Kaisho T, Kaufmann J, McEachern K, Soliman H, Luca VC, Rodriguez PC, Yu X, Ruffell B. de Mingo Pulido Á, et al. Among authors: kaisho t. Immunity. 2021 Jun 8;54(6):1154-1167.e7. doi: 10.1016/j.immuni.2021.04.019. Epub 2021 May 11. Immunity. 2021. PMID: 33979578 Free PMC article.
T cell-specific loss of Pten leads to defects in central and peripheral tolerance.
Suzuki A, Yamaguchi MT, Ohteki T, Sasaki T, Kaisho T, Kimura Y, Yoshida R, Wakeham A, Higuchi T, Fukumoto M, Tsubata T, Ohashi PS, Koyasu S, Penninger JM, Nakano T, Mak TW. Suzuki A, et al. Among authors: kaisho t. Immunity. 2001 May;14(5):523-34. doi: 10.1016/s1074-7613(01)00134-0. Immunity. 2001. PMID: 11371355 Free article.
Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β.
Kawashima T, Kosaka A, Yan H, Guo Z, Uchiyama R, Fukui R, Kaneko D, Kumagai Y, You DJ, Carreras J, Uematsu S, Jang MH, Takeuchi O, Kaisho T, Akira S, Miyake K, Tsutsui H, Saito T, Nishimura I, Tsuji NM. Kawashima T, et al. Among authors: kaisho t. Immunity. 2013 Jun 27;38(6):1187-97. doi: 10.1016/j.immuni.2013.02.024. Epub 2013 Jun 20. Immunity. 2013. PMID: 23791646 Free article.
CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming.
Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W. Brewitz A, et al. Among authors: kaisho t. Immunity. 2017 Feb 21;46(2):205-219. doi: 10.1016/j.immuni.2017.01.003. Epub 2017 Feb 9. Immunity. 2017. PMID: 28190711 Free PMC article.
Anticancer effects of chemokine-directed antigen delivery to a cross-presenting dendritic cell subset with immune checkpoint blockade.
Mizumoto Y, Hemmi H, Katsuda M, Miyazawa M, Kitahata Y, Miyamoto A, Nakamori M, Ojima T, Matsuda K, Nakamura M, Hayata K, Fukuda-Ohta Y, Sugiyama M, Ohta T, Orimo T, Okura S, Sasaki I, Tamada K, Yamaue H, Kaisho T. Mizumoto Y, et al. Among authors: kaisho t. Br J Cancer. 2020 Apr;122(8):1185-1193. doi: 10.1038/s41416-020-0757-2. Epub 2020 Feb 18. Br J Cancer. 2020. PMID: 32066911 Free PMC article.
Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches.
Dähling S, Mansilla AM, Knöpper K, Grafen A, Utzschneider DT, Ugur M, Whitney PG, Bachem A, Arampatzi P, Imdahl F, Kaisho T, Zehn D, Klauschen F, Garbi N, Kallies A, Saliba AE, Gasteiger G, Bedoui S, Kastenmüller W. Dähling S, et al. Among authors: kaisho t. Immunity. 2022 Apr 12;55(4):656-670.e8. doi: 10.1016/j.immuni.2022.03.006. Epub 2022 Apr 1. Immunity. 2022. PMID: 35366396 Free article.
Conventional Type 1 Dendritic Cells in Intestinal Immune Homeostasis.
Sasaki I, Kato T, Hemmi H, Fukuda-Ohta Y, Wakaki-Nishiyama N, Yamamoto A, Kaisho T. Sasaki I, et al. Among authors: kaisho t. Front Immunol. 2022 May 27;13:857954. doi: 10.3389/fimmu.2022.857954. eCollection 2022. Front Immunol. 2022. PMID: 35693801 Free PMC article. Review.
194 results