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The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease.
Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR. Lamb J, et al. Among authors: subramanian a. Science. 2006 Sep 29;313(5795):1929-35. doi: 10.1126/science.1132939. Science. 2006. PMID: 17008526
Molecular signatures database (MSigDB) 3.0.
Liberzon A, Subramanian A, Pinchback R, Thorvaldsdóttir H, Tamayo P, Mesirov JP. Liberzon A, et al. Among authors: subramanian a. Bioinformatics. 2011 Jun 15;27(12):1739-40. doi: 10.1093/bioinformatics/btr260. Epub 2011 May 5. Bioinformatics. 2011. PMID: 21546393 Free PMC article.
An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.
Olson DE, Udeshi ND, Wolfson NA, Pitcairn CA, Sullivan ED, Jaffe JD, Svinkina T, Natoli T, Lu X, Paulk J, McCarren P, Wagner FF, Barker D, Howe E, Lazzaro F, Gale JP, Zhang YL, Subramanian A, Fierke CA, Carr SA, Holson EB. Olson DE, et al. Among authors: subramanian a. ACS Chem Biol. 2014 Oct 17;9(10):2210-6. doi: 10.1021/cb500492r. Epub 2014 Aug 11. ACS Chem Biol. 2014. PMID: 25089360 Free PMC article.
Gene expression inference with deep learning.
Chen Y, Li Y, Narayan R, Subramanian A, Xie X. Chen Y, et al. Among authors: subramanian a. Bioinformatics. 2016 Jun 15;32(12):1832-9. doi: 10.1093/bioinformatics/btw074. Epub 2016 Feb 11. Bioinformatics. 2016. PMID: 26873929 Free PMC article.
Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.
Kim E, Ilic N, Shrestha Y, Zou L, Kamburov A, Zhu C, Yang X, Lubonja R, Tran N, Nguyen C, Lawrence MS, Piccioni F, Bagul M, Doench JG, Chouinard CR, Wu X, Hogstrom L, Natoli T, Tamayo P, Horn H, Corsello SM, Lage K, Root DE, Subramanian A, Golub TR, Getz G, Boehm JS, Hahn WC. Kim E, et al. Among authors: subramanian a. Cancer Discov. 2016 Jul;6(7):714-26. doi: 10.1158/2159-8290.CD-16-0160. Epub 2016 May 4. Cancer Discov. 2016. PMID: 27147599 Free PMC article.
High-throughput Phenotyping of Lung Cancer Somatic Mutations.
Berger AH, Brooks AN, Wu X, Shrestha Y, Chouinard C, Piccioni F, Bagul M, Kamburov A, Imielinski M, Hogstrom L, Zhu C, Yang X, Pantel S, Sakai R, Watson J, Kaplan N, Campbell JD, Singh S, Root DE, Narayan R, Natoli T, Lahr DL, Tirosh I, Tamayo P, Getz G, Wong B, Doench J, Subramanian A, Golub TR, Meyerson M, Boehm JS. Berger AH, et al. Among authors: subramanian a. Cancer Cell. 2016 Aug 8;30(2):214-228. doi: 10.1016/j.ccell.2016.06.022. Epub 2016 Jul 28. Cancer Cell. 2016. PMID: 27478040 Free PMC article.
The Drug Repurposing Hub: a next-generation drug library and information resource.
Corsello SM, Bittker JA, Liu Z, Gould J, McCarren P, Hirschman JE, Johnston SE, Vrcic A, Wong B, Khan M, Asiedu J, Narayan R, Mader CC, Subramanian A, Golub TR. Corsello SM, et al. Among authors: subramanian a. Nat Med. 2017 Apr 7;23(4):405-408. doi: 10.1038/nm.4306. Nat Med. 2017. PMID: 28388612 Free PMC article. No abstract available.
1,185 results