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The Widely Used Antihelmintic Drug Albendazole is a Potent Inducer of Loss of Heterozygosity.
Will Castro LSEP, Pieters W, Alemdehy MF, Aslam MA, Buoninfante OA, Raaijmakers JA, Pilzecker B, van den Berk PCM, Te Riele H, Medema RH, Pedrosa RC, Jacobs H. Will Castro LSEP, et al. Among authors: alemdehy mf. Front Pharmacol. 2021 Feb 18;12:596535. doi: 10.3389/fphar.2021.596535. eCollection 2021. Front Pharmacol. 2021. PMID: 33679394 Free PMC article.
The Ig heavy chain protein but not its message controls early B cell development.
Aslam MA, Alemdehy MF, Hao B, Krijger PHL, Pritchard CEJ, de Rink I, Muhaimin FI, Nurzijah I, van Baalen M, Kerkhoven RM, van den Berk PCM, Skok JA, Jacobs H. Aslam MA, et al. Among authors: alemdehy mf. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31343-31352. doi: 10.1073/pnas.2004810117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229554 Free PMC article.
Towards an understanding of C9orf82 protein/CAAP1 function.
Aslam MA, Alemdehy MF, Pritchard CEJ, Song JY, Muhaimin FI, Wijdeven RH, Huijbers IJ, Neefjes J, Jacobs H. Aslam MA, et al. Among authors: alemdehy mf. PLoS One. 2019 Jan 10;14(1):e0210526. doi: 10.1371/journal.pone.0210526. eCollection 2019. PLoS One. 2019. PMID: 30629682 Free PMC article.
Histone methyltransferase DOT1L controls state-specific identity during B cell differentiation.
Aslam MA, Alemdehy MF, Kwesi-Maliepaard EM, Muhaimin FI, Caganova M, Pardieck IN, van den Brand T, van Welsem T, de Rink I, Song JY, de Wit E, Arens R, Jacobs H, van Leeuwen F. Aslam MA, et al. Among authors: alemdehy mf. EMBO Rep. 2021 Feb 3;22(2):e51184. doi: 10.15252/embr.202051184. Epub 2021 Jan 7. EMBO Rep. 2021. PMID: 33410591 Free PMC article.
The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells.
Kwesi-Maliepaard EM, Aslam MA, Alemdehy MF, van den Brand T, McLean C, Vlaming H, van Welsem T, Korthout T, Lancini C, Hendriks S, Ahrends T, van Dinther D, den Haan JMM, Borst J, de Wit E, van Leeuwen F, Jacobs H. Kwesi-Maliepaard EM, et al. Among authors: alemdehy mf. Proc Natl Acad Sci U S A. 2020 Aug 25;117(34):20706-20716. doi: 10.1073/pnas.1920372117. Epub 2020 Aug 6. Proc Natl Acad Sci U S A. 2020. PMID: 32764145 Free PMC article.
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.
Vlaming H, McLean CM, Korthout T, Alemdehy MF, Hendriks S, Lancini C, Palit S, Klarenbeek S, Kwesi-Maliepaard EM, Molenaar TM, Hoekman L, Schmidlin TT, Altelaar AM, van Welsem T, Dannenberg JH, Jacobs H, van Leeuwen F. Vlaming H, et al. Among authors: alemdehy mf. EMBO J. 2019 Jul 15;38(14):e101564. doi: 10.15252/embj.2019101564. Epub 2019 Jun 17. EMBO J. 2019. PMID: 31304633 Free PMC article.
ICL-induced miR139-3p and miR199a-3p have opposite roles in hematopoietic cell expansion and leukemic transformation.
Alemdehy MF, Haanstra JR, de Looper HW, van Strien PM, Verhagen-Oldenampsen J, Caljouw Y, Sanders MA, Hoogenboezem R, de Ru AH, Janssen GM, Smetsers SE, Bierings MB, van Veelen PA, von Lindern M, Touw IP, Erkeland SJ. Alemdehy MF, et al. Blood. 2015 Jun 18;125(25):3937-48. doi: 10.1182/blood-2014-11-612507. Epub 2015 Mar 16. Blood. 2015. PMID: 25778535 Free article.
MicroRNA-155 induces AML in combination with the loss of C/EBPA in mice.
Alemdehy MF, de Looper HW, Kavelaars FG, Sanders MA, Hoogenboezem R, Löwenberg B, Valk PJ, Touw IP, Erkeland SJ. Alemdehy MF, et al. Leukemia. 2016 Nov;30(11):2238-2241. doi: 10.1038/leu.2016.171. Epub 2016 Jun 4. Leukemia. 2016. PMID: 27363282 No abstract available.
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