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An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Nguyen MT, Moiani D, Ahmed Z, Arvai AS, Namjoshi S, Shin DS, Fedorov Y, Selvik EJ, Jones DE, Pink J, Yan Y, Laverty DJ, Nagel ZD, Tainer JA, Gerson SL. Nguyen MT, et al. Among authors: pink j. Prog Biophys Mol Biol. 2021 Aug;163:143-159. doi: 10.1016/j.pbiomolbio.2021.02.004. Epub 2021 Mar 3. Prog Biophys Mol Biol. 2021. PMID: 33675849 Free PMC article.
Adding Base-Excision Repair Inhibitor TRC102 to Standard Pemetrexed-Platinum-Radiation in Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer: Results of a Phase I Trial.
Biswas T, Dowlati A, Kunos CA, Pink JJ, Oleinick NL, Malik S, Fu P, Cao S, Bruno DS, Bajor DL, Patel M, Gerson SL, Machtay M. Biswas T, et al. Among authors: pink jj. Clin Cancer Res. 2022 Feb 15;28(4):646-652. doi: 10.1158/1078-0432.CCR-21-2025. Clin Cancer Res. 2022. PMID: 34740922 Free PMC article. Clinical Trial.
Phase I clinical trial of temozolomide and methoxyamine (TRC-102), an inhibitor of base excision repair, in patients with advanced solid tumors.
Eads JR, Krishnamurthi SS, Saltzman J, Bokar JA, Savvides P, Meropol NJ, Gibbons J, Koon H, Sharma N, Rogers L, Pink JJ, Xu Y, Beumer JH, Riendeau J, Fu P, Gerson SL, Dowlati A. Eads JR, et al. Among authors: pink jj. Invest New Drugs. 2021 Feb;39(1):142-151. doi: 10.1007/s10637-020-00962-x. Epub 2020 Jun 17. Invest New Drugs. 2021. PMID: 32556884 Free PMC article. Clinical Trial.
287 results