Loadman PM - Search Results

1

An assay for quantitative analysis of polysialic acid expression in cancer cells.

Guo X, Elkashef SM, Patel A, Ribeiro Morais G, Shnyder SD, Loadman PM, Patterson LH, Falconer RA. Guo X, et al. Among authors: loadman pm. Carbohydr Polym. 2021 May 1;259:117741. doi: 10.1016/j.carbpol.2021.117741. Epub 2021 Feb 2. Carbohydr Polym. 2021. PMID: 33674001

2

High-performance liquid chromatographic analysis of AQ4N, an alkylaminoanthraquinone N-oxide.

Swaine DJ, Loadman PM, Bibby MC, Graham MA, Patterson LH. Swaine DJ, et al. Among authors: loadman pm. J Chromatogr B Biomed Sci Appl. 2000 Jun 9;742(2):239-45. doi: 10.1016/s0378-4347(00)00160-2. J Chromatogr B Biomed Sci Appl. 2000. PMID: 10901128

3

A preclinical pharmacokinetic study of the bioreductive drug AQ4N.

Loadman PM, Swaine DJ, Bibby MC, Welham KJ, Patterson LH. Loadman PM, et al. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):422-6. Drug Metab Dispos. 2001. PMID: 11259326

4

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs.

Phillips RM, Jaffar M, Maitland DJ, Loadman PM, Shnyder SD, Steans G, Cooper PA, Race A, Patterson AV, Stratford IJ. Phillips RM, et al. Among authors: loadman pm. Biochem Pharmacol. 2004 Dec 1;68(11):2107-16. doi: 10.1016/j.bcp.2004.08.007. Biochem Pharmacol. 2004. PMID: 15498501

5

Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates.

Wells G, Martin CR, Howard PW, Sands ZA, Laughton CA, Tiberghien A, Woo CK, Masterson LA, Stephenson MJ, Hartley JA, Jenkins TC, Shnyder SD, Loadman PM, Waring MJ, Thurston DE. Wells G, et al. Among authors: loadman pm. J Med Chem. 2006 Sep 7;49(18):5442-61. doi: 10.1021/jm051199z. J Med Chem. 2006. PMID: 16942018

6

Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry.

Atkinson SJ, Loadman PM, Sutton C, Patterson LH, Clench MR. Atkinson SJ, et al. Among authors: loadman pm. Rapid Commun Mass Spectrom. 2007;21(7):1271-6. doi: 10.1002/rcm.2952. Rapid Commun Mass Spectrom. 2007. PMID: 17340571

7

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.

Williams KJ, Albertella MR, Fitzpatrick B, Loadman PM, Shnyder SD, Chinje EC, Telfer BA, Dunk CR, Harris PA, Stratford IJ. Williams KJ, et al. Among authors: loadman pm. Mol Cancer Ther. 2009 Dec;8(12):3266-75. doi: 10.1158/1535-7163.MCT-09-0396. Mol Cancer Ther. 2009. PMID: 19996276

8

Development of a novel tumor-targeted vascular disrupting agent activated by membrane-type matrix metalloproteinases.

Atkinson JM, Falconer RA, Edwards DR, Pennington CJ, Siller CS, Shnyder SD, Bibby MC, Patterson LH, Loadman PM, Gill JH. Atkinson JM, et al. Among authors: loadman pm. Cancer Res. 2010 Sep 1;70(17):6902-12. doi: 10.1158/0008-5472.CAN-10-1440. Epub 2010 Jul 27. Cancer Res. 2010. PMID: 20663911 Free PMC article.

9

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity.

Pors K, Loadman PM, Shnyder SD, Sutherland M, Sheldrake HM, Guino M, Kiakos K, Hartley JA, Searcey M, Patterson LH. Pors K, et al. Among authors: loadman pm. Chem Commun (Camb). 2011 Nov 28;47(44):12062-4. doi: 10.1039/c1cc15638a. Epub 2011 Oct 14. Chem Commun (Camb). 2011. PMID: 22002321

10

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

Sutherland M, Gill JH, Loadman PM, Laye JP, Sheldrake HM, Illingworth NA, Alandas MN, Cooper PA, Searcey M, Pors K, Shnyder SD, Patterson LH. Sutherland M, et al. Among authors: loadman pm. Mol Cancer Ther. 2013 Jan;12(1):27-37. doi: 10.1158/1535-7163.MCT-12-0405. Epub 2012 Oct 1. Mol Cancer Ther. 2013. PMID: 23033491

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