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In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.
Rothgangl T, Dennis MK, Lin PJC, Oka R, Witzigmann D, Villiger L, Qi W, Hruzova M, Kissling L, Lenggenhager D, Borrelli C, Egli S, Frey N, Bakker N, Walker JA 2nd, Kadina AP, Victorov DV, Pacesa M, Kreutzer S, Kontarakis Z, Moor A, Jinek M, Weissman D, Stoffel M, van Boxtel R, Holden K, Pardi N, Thöny B, Häberle J, Tam YK, Semple SC, Schwank G. Rothgangl T, et al. Among authors: kontarakis z. Nat Biotechnol. 2021 Aug;39(8):949-957. doi: 10.1038/s41587-021-00933-4. Epub 2021 May 19. Nat Biotechnol. 2021. PMID: 34012094 Free PMC article.
In vivo prime editing of a metabolic liver disease in mice.
Böck D, Rothgangl T, Villiger L, Schmidheini L, Matsushita M, Mathis N, Ioannidi E, Rimann N, Grisch-Chan HM, Kreutzer S, Kontarakis Z, Kopf M, Thöny B, Schwank G. Böck D, et al. Among authors: kontarakis z. Sci Transl Med. 2022 Mar 16;14(636):eabl9238. doi: 10.1126/scitranslmed.abl9238. Epub 2022 Mar 16. Sci Transl Med. 2022. PMID: 35294257 Free PMC article.
Genetics in Light of Transcriptional Adaptation.
Kontarakis Z, Stainier DYR. Kontarakis Z, et al. Trends Genet. 2020 Dec;36(12):926-935. doi: 10.1016/j.tig.2020.08.008. Epub 2020 Sep 11. Trends Genet. 2020. PMID: 32928563 Free PMC article. Review.
Making sense of anti-sense data.
Stainier DY, Kontarakis Z, Rossi A. Stainier DY, et al. Among authors: kontarakis z. Dev Cell. 2015 Jan 12;32(1):7-8. doi: 10.1016/j.devcel.2014.12.012. Dev Cell. 2015. PMID: 25584794 Free article.
Mir-126 is a conserved modulator of lymphatic development.
Kontarakis Z, Rossi A, Ramas S, Dellinger MT, Stainier DYR. Kontarakis Z, et al. Dev Biol. 2018 May 15;437(2):120-130. doi: 10.1016/j.ydbio.2018.03.006. Epub 2018 Mar 15. Dev Biol. 2018. PMID: 29550364 Free article.
Genetic compensation triggered by mutant mRNA degradation.
El-Brolosy MA, Kontarakis Z, Rossi A, Kuenne C, Günther S, Fukuda N, Kikhi K, Boezio GLM, Takacs CM, Lai SL, Fukuda R, Gerri C, Giraldez AJ, Stainier DYR. El-Brolosy MA, et al. Among authors: kontarakis z. Nature. 2019 Apr;568(7751):193-197. doi: 10.1038/s41586-019-1064-z. Epub 2019 Apr 3. Nature. 2019. PMID: 30944477 Free PMC article.
23 results