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O6-methylguanine-DNA methyltransferase (MGMT) transfectants of a 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU)-sensitive colon cancer cell line selectively repopulate heterogenous MGMT+/MGMT- xenografts after BCNU and O6-benzylguanine plus BCNU.
Phillips WP Jr, Willson JK, Markowitz SD, Zborowska E, Zaidi NH, Liu L, Gordon NH, Gerson SL. Phillips WP Jr, et al. Among authors: markowitz sd. Cancer Res. 1997 Nov 1;57(21):4817-23. Cancer Res. 1997. PMID: 9354444
Focus on colon cancer.
Markowitz SD, Dawson DM, Willis J, Willson JK. Markowitz SD, et al. Cancer Cell. 2002 Apr;1(3):233-6. doi: 10.1016/s1535-6108(02)00053-3. Cancer Cell. 2002. PMID: 12086859 Free article. Review. No abstract available.
15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers.
Yan M, Rerko RM, Platzer P, Dawson D, Willis J, Tong M, Lawrence E, Lutterbaugh J, Lu S, Willson JK, Luo G, Hensold J, Tai HH, Wilson K, Markowitz SD. Yan M, et al. Among authors: markowitz sd. Proc Natl Acad Sci U S A. 2004 Dec 14;101(50):17468-73. doi: 10.1073/pnas.0406142101. Epub 2004 Dec 1. Proc Natl Acad Sci U S A. 2004. PMID: 15574495 Free PMC article.
15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis.
Myung SJ, Rerko RM, Yan M, Platzer P, Guda K, Dotson A, Lawrence E, Dannenberg AJ, Lovgren AK, Luo G, Pretlow TP, Newman RA, Willis J, Dawson D, Markowitz SD. Myung SJ, et al. Among authors: markowitz sd. Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12098-102. doi: 10.1073/pnas.0603235103. Epub 2006 Jul 31. Proc Natl Acad Sci U S A. 2006. PMID: 16880406 Free PMC article.
15-Hydroxyprostaglandin dehydrogenase inactivation as a mechanism of resistance to celecoxib chemoprevention of colon tumors.
Yan M, Myung SJ, Fink SP, Lawrence E, Lutterbaugh J, Yang P, Zhou X, Liu D, Rerko RM, Willis J, Dawson D, Tai HH, Barnholtz-Sloan JS, Newman RA, Bertagnolli MM, Markowitz SD. Yan M, et al. Among authors: markowitz sd. Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9409-13. doi: 10.1073/pnas.0902367106. Epub 2009 May 22. Proc Natl Acad Sci U S A. 2009. PMID: 19470469 Free PMC article. Clinical Trial.
266 results