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TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP, Tiwari S, Willis JE, Williams NS, Dawson DM, Wald D, Chen WD, Wang Z, Kasturi L, Larusch GA, He L, Cominelli F, Di Martino L, Djuric Z, Milne GL, Chance M, Sanabria J, Dealwis C, Mikkola D, Naidoo J, Wei S, Tai HH, Gerson SL, Ready JM, Posner B, Willson JK, Markowitz SD. Zhang Y, et al. Among authors: gerson sl. Science. 2015 Jun 12;348(6240):aaa2340. doi: 10.1126/science.aaa2340. Science. 2015. PMID: 26068857 Free PMC article.
A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support.
Desai A, Zhang Y, Park Y, Dawson DM, Larusch GA, Kasturi L, Wald D, Ready JM, Gerson SL, Markowitz SD. Desai A, et al. Among authors: gerson sl. Haematologica. 2018 Jun;103(6):1054-1064. doi: 10.3324/haematol.2017.178376. Epub 2018 Feb 22. Haematologica. 2018. PMID: 29472361 Free PMC article.
Inhibition of 15-PGDH Protects Mice from Immune-Mediated Bone Marrow Failure.
Smith JNP, Otegbeye F, Jogasuria AP, Christo KF, Antczak MI, Ready JM, Gerson SL, Markowitz SD, Desai AB. Smith JNP, et al. Among authors: gerson sl. Biol Blood Marrow Transplant. 2020 Aug;26(8):1552-1556. doi: 10.1016/j.bbmt.2020.04.010. Epub 2020 May 15. Biol Blood Marrow Transplant. 2020. PMID: 32422251 Free PMC article.
15-PGDH regulates hematopoietic and gastrointestinal fitness during aging.
Ho WJ, Smith JNP, Park YS, Hadiono M, Christo K, Jogasuria A, Zhang Y, Broncano AV, Kasturi L, Dawson DM, Gerson SL, Markowitz SD, Desai AB. Ho WJ, et al. Among authors: gerson sl. PLoS One. 2022 May 19;17(5):e0268787. doi: 10.1371/journal.pone.0268787. eCollection 2022. PLoS One. 2022. PMID: 35587945 Free PMC article.
288 results